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549-18-8

Name Amitriptyline hydrochloride
CAS 549-18-8
EINECS(EC#) 208-964-6
Molecular Formula C20H24ClN
MDL Number MFCD00012537
Molecular Weight 313.86
MOL File 549-18-8.mol

Chemical Properties

Melting point  196-197°C
Fp  11 °C
storage temp.  2-8°C
solubility  H2O: soluble
form  powder
pka 9.4(at 25℃)
color  white to off-white
PH 4.5~6.0 (10g/l, 25℃)
Water Solubility  almost transparency
Merck  487
BCS Class 1
CAS DataBase Reference 549-18-8(CAS DataBase Reference)
EPA Substance Registry System 549-18-8(EPA Substance)

Safety Data

Hazard Codes  T,F
Risk Statements 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact .
R63:Possible risk of harm to the unborn child.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
Safety Statements 
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HO9450000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29214990
Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: convulsions, respiratory depression, changes in sleep, hallucinations, muscle contractions, somnolence, blood pressure decrease, coma, cyanosis, dyspnea, and ataxia. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also ELAVIL.
Hazardous Substances Data 549-18-8(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (mg/kg): 350, 380 orally; 65, 75 i.p. (Tobe)

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