ChemicalBook CAS DataBase List 96020-91-6

96020-91-6

Name	Eflornithine hydrochloride hydrate
CAS	96020-91-6
Molecular Formula	C6H12F2N2O2
MDL Number	MFCD00242734
Molecular Weight	236.65
MOL File	96020-91-6.mol

Chemical Properties

Melting point	>210°C (dec.)
storage temp.	-20°C Freezer
solubility	Soluble in Water (up to 25 mg/ml).
form	White powder
color	White
Merck	14,3522
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference	96020-91-6

Safety Data

RTECS	RM2981900
HS Code	2922493800

Hazard Information

Description

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.

Chemical Properties

White Solid

Uses

Eflornithine hydrochloride hydrate is an Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis.It is used in the treatment of hirsutism.

Definition

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

Brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

General Description

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Biological Activity

Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor.

Biochem/physiol Actions

Primary TargetODC

storage

Store at -20°C

References

1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945

Spectrum Detail

Supplier

Beijing Nordhuns Chemical Technology Co.,Ltd

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Wuhan Xinru Chemical Co., Ltd.

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9ding chemical ( Shanghai) Limited

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