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77-78-1

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Identification

Name
Dimethyl sulfate
CAS
77-78-1
Synonyms
AKOS BBS-00004221
DIMETHYL SULFATE
DIMETHYL SULPHATE
METHYL SULFATE
SULFURIC ACID DIMETHYL ESTER
SULPHURIC ACID DIMETHYL ESTER
ai3-52118
Dimethoxysulfone
Dimethyl monosulfate
Dimethylester kyseliny sirove
dimethylesterkyselinysirove
dimethylesterkyselinysirove(czech)
dimethylmonosulfate
Dimethylsulfaat
Dimethylsulfat
dimethylsulfat(czech)
Dimetilsolfato
DMS (Methyl sulfate)
dms(methylsulfate)
Dwumetylowy siarczan
EINECS(EC#)
201-058-1
Molecular Formula
C2H6O4S
MDL Number
MFCD00008416
Molecular Weight
126.13
MOL File
77-78-1.mol

Chemical Properties

Appearance
colourless liquid
mp 
-32 °C
bp 
188 °C(lit.)

density 
1.333 g/mL at 25 °C(lit.)

vapor density 
4.3 (vs air)

vapor pressure 
0.7 mm Hg ( 25 °C)

refractive index 
n20/D 1.386(lit.)

Fp 
182 °F

storage temp. 
2-8°C

solubility 
ethanol: 0.26 g/mL, clear, colorless

Stability:
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
Water Solubility 
2.8 g/100 mL (18 ºC)
Merck 
13,3282
CAS DataBase Reference
77-78-1(CAS DataBase Reference)
NIST Chemistry Reference
Sulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry System
77-78-1(EPA Substance)

Safety Data

Hazard Codes 
T+
Risk Statements 
R45:May cause cancer.
R25:Toxic if swallowed.
R26:Very Toxic by inhalation.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R68:Possible risk of irreversible effects.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR 
UN 1595 6.1/PG 1

WGK Germany 
2

RTECS 
WS8225000


21
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29209090
Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.
Hazardous Substances Data
77-78-1(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
DIMETHYL SULFATE(77-78-1) is a colorless oily liquid, odorless to a faint onion-like odor. DIMETHYL SULFATE(77-78-1) is very toxic by inhalation. DIMETHYL SULFATE(77-78-1) is a combustible liquid and has a flash point of 182°F. DIMETHYL SULFATE(77-78-1) is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. DIMETHYL SULFATE(77-78-1) is corrosive to metals and tissue.
Reactivity Profile
Pure DIMETHYL SULFATE and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as dimethyl sulfate, [MCA Case History No. 1786].
Air & Water Reactions
Water soluble.
Health Hazard
Acute: extremely toxic vapors and liquid--a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities.
Fire Hazard
Material is normally stable even under fire exposure conditions and is not hazardously reactive with water. DIMETHYL SULFATE is incompatible with strong oxidizers and strong ammonia solutions.

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Dimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate.
Dimethyl sulfate
In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.
Chemical Properties
Dimethyl sulfate is a colorless, oily liquid that is slightly soluble in water. It has a faint, onion-like odor; the odor threshold has not been established. The vapor pressure for dimethyl sulfate is 0.5 mm Hg at 20 °C, and it has a log octanol/water partition coefficient (log Kow ) of 0.032.
Uses
Dimethyl sulphate has been used since the beginning of the century as a methylating agent in the preparation of organic chemical products and colouring agents, in the perfume industry, and in other processes. It is a colourless or yellowish liquid of oily consistency which vaporizes at 50℃. and has a slight piquant smell. Both the liquid and the vapour are vesicants and by virtue of this property may be used in warfare.
References
https://en.wikipedia.org/wiki/Dimethyl_sulfate
https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl_sulfate#section=Top

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