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Name Dimethyl sulfate
CAS 77-78-1
EINECS(EC#) 201-058-1
Molecular Formula C2H6O4S
MDL Number MFCD00008416
Molecular Weight 126.13
MOL File 77-78-1.mol

Chemical Properties

Appearance colourless liquid
Melting point  -32 °C
Boiling point  188 °C(lit.)
density  1.333 g/mL at 25 °C(lit.)
vapor density  4.3 (vs air)
vapor pressure  0.7 mm Hg ( 25 °C)
refractive index  n20/D 1.386(lit.)
Fp  182 °F
storage temp.  2-8°C
solubility  ethanol: 0.26 g/mL, clear, colorless
form  Liquid
color  Clear colorless
Odor Almost odorless
Stability: Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
Water Solubility  2.8 g/100 mL (18 ºC)
Merck  13,3282
BRN  635994
Dielectric constant 55.0(20℃)
Exposure limits TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
CAS DataBase Reference 77-78-1(CAS DataBase Reference)
IARC 2A (Vol. 4, Sup 7, 71) 1999
NIST Chemistry Reference Sulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry System 77-78-1(EPA Substance)

Safety Data

Hazard Codes  T+
Risk Statements 
R45:May cause cancer.
R25:Toxic if swallowed.
R26:Very Toxic by inhalation.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R68:Possible risk of irreversible effects.
Safety Statements 
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
RIDADR  UN 1595 6.1/PG 1
WGK Germany  2
RTECS  WS8225000
Autoignition Temperature 495 °C
HazardClass  6.1(a)
PackingGroup  I
HS Code  29209090
Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.
Hazardous Substances Data 77-78-1(Hazardous Substances Data)
LD50 orally in rats: 440 mg/kg (Smyth)
IDLA 7 ppm

Hazard Information

Material Safety Data Sheet(MSDS)

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