ChemicalBook CAS DataBase List 125-10-0

125-10-0

Name	Prednisone 21-acetate
CAS	125-10-0
EINECS(EC#)	204-726-0
Molecular Formula	C23H28O6
MDL Number	MFCD00200229
Molecular Weight	400.46
MOL File	125-10-0.mol

Synonyms

1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 21-ACETATE 1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 21-ACETATE 17 ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,11,20-TRIONE-21-ACETATE 1-DEHYDROCORTISONE ACETATE [2-[(8s,9s,10s,13s,14s,17r)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate ACETIC ACID 2-((8S,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3,11-DIOXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER prednisone 21-acetate PREDNISONE ACETATE 11,20-trione,21-(acetyloxy)-17-hydroxy-pregna-4-diene-3 4-diene-3,11,20-trione,17,21-dihydroxy-pregna-21-acetate delcortin delta’-dehydrocortisoneacetate delta-corlin deltalone nisone Dehydrocortisone acetate 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione-21-acetate 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trioneacetate [2-[(8S,9S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate

Chemical Properties

Melting point	240-242°C (dec.)
alpha	D25 +186° (dioxane)
Boiling point	582.0±50.0 °C(Predicted)
density	1.28±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	12.31±0.60(Predicted)
color	White to Off-White
Water Solubility	23mg/L(25 ºC)
InChIKey	MOVRKLZUVNCBIP-RFZYENFJSA-N
SMILES	C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1=O)(C)[C@@](O)(C(=O)COC(C)=O)CC3)CC2
CAS DataBase Reference	125-10-0(CAS DataBase Reference)

Safety Data

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361-H373
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P260-P314-P501
REACH Registrations	Active

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White Solid

Uses

Adrenocortical steroid antiinflammatory.

Definition

ChEBI: Cortancyl is a steroid ester, a 20-oxo steroid, an acetate ester, a 17alpha-hydroxy steroid, an 11-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It is functionally related to a prednisone.

in vivo

Prednisone acetate (5 mg/kg, Intragastric gavage, once a day for 4 weeks) induces hippocampal LTP impairment by causing neuronal lesions in the dentate gyrus, which reduced glutamic acid (Glu) and NMDAR2A, and impaired spatial memory in Hippocampal LTP impairment model mice^[1].
Prednisone acetate (6 mg/kg, gavage, once a day for 15 days) reduces ocular and peripheral inflammatory responses and restores Th1/Th2 and Th17/Treg immune homeostasis through orchestrating the Notch signaling pathway in Experimental autoimmune uveitis (EAU) rats^[2].

Animal Model:	C57BL/6 mice ^[1]
Dosage:	5 mg/kg
Administration:	Intragastric gavage (i.g.)
Result:	Significantly failed to gain weight. Decreased the population spike (%) after high-frequency stimulation. Reduced the crossing times compared with the control group. Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.

Animal Model:	Experimental autoimmune uveitis ^[2]
Dosage:	6 mg/kg
Administration:	gavage
Result:	Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation. Decreased Th1, Th17 and increased Th2, Treg frequencies in EAU.

IC 50

IL-17; IL-10; IL-4

Spectrum Detail

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