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53-03-2

Name Prednisone
CAS 53-03-2
EINECS(EC#) 200-160-3
Molecular Formula C21H26O5
MDL Number MFCD00003608
Molecular Weight 358.43
MOL File 53-03-2.mol

Chemical Properties

Appearance white crystalline powder
Melting point  236-238 °C(lit.)
alpha  169 º (c=0.5, dioxane)
Boiling point  410.86°C (rough estimate)
density  1.1121 (rough estimate)
refractive index  170 ° (C=0.5, Dioxane)
Fp  >200℃
storage temp.  2-8°C
solubility  Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9).
form  Solid
pka 12.36±0.60(Predicted)
color  White to Off-White
Stability: Stable. Incompatible with strong oxidizing agents.
Water Solubility  115mg/L(25 ºC)
Merck  7722
BRN  2065301
CAS DataBase Reference 53-03-2(CAS DataBase Reference)
IARC 3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference Prednisone(53-03-2)
EPA Substance Registry System 53-03-2(EPA Substance)

Safety Data

Hazard Codes  Xn
Risk Statements 
R63:Possible risk of harm to the unborn child.
R34:Causes burns.
R11:Highly Flammable.
Safety Statements 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Hazardous Substances Data 53-03-2(Hazardous Substances Data)

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