147245-92-9

Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.

Copaxone,Teva Pharmaceuticals,Israel

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000.
Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Copaxone (Teva).

Immunomodulator

Glatiramer acetatea myelin basic protein mimeticis an immunomodulator used for treatment of Multiple Sclerosis. Glatiramer acetate is a mixture of synthetic peptides randomly composed of glutamic acidlysinealanineand tyrosine. It reduces relapse rate and disease progression in Multiple Sclerosis. Its mechanism of action is not fully understood. Glatiramer acetate generates anti-inflammatory Th2 cellswhich produce neurotrophic factors.

Immunomodulating drug:

Treatment for patients at a high risk of developing multiple sclerosis and for reduction in relapses in ambulatory patients

Potentially hazardous interactions with other drugs
None known

A substantial fraction of a subcutaneous dose of glatiramer is believed to be hydrolysed locally. Some of the injected dose is also presumed to enter the lymphatic system, either intact or partially hydrolysed.