69558-55-0

TP is a polypeptide extracted from the calf thymus. Two similar types have been identified: thymopoietin-I (TP-I) and thymopoietin-II (TP-II). TP-II is a 49-mer peptide composed of 13 amino acids. The structural difference between TP-I and TP-II is that the amino acids Se1 and Se43 in the TP-II peptide chain are replaced by Gly1 and Se43 in TP-I. The pentapeptide consisting of Se32-Thr36 has demonstrated T cell differentiation activity in vitro and in vivo. Five of the 49 amino acids are physiologically active. The synthetic lysine-valine penta-peptide, timopentin, has been synthesized and is currently in clinical use. Furthermore, splenin, isolated from bovine spleen, is similar to TP-II and is therefore designated TP-III. The synthetic TP-II penta-peptide is tentatively referred to as thymosynthetin (TPe), and the synthetic TP-III penta-peptide is tentatively referred to as splenosytin (SPe). TP-II and TPe act on neuromuscular transmission, inducing the in vitro differentiation of T cell precursors while inhibiting B cell differentiation. TP-III and SPe can induce the differentiation of T and B cell precursors. Ubiquitin, composed of 74 amino acid residues, can induce the differentiation of both T and B cells. It is widely present in animal tissues (including the thymus) and plant and fungal cells, and is associated with immune function.

Janssen (Belgium)

immunoregulator

ChEBI: Thymopentin is an oligopeptide.

SINTOMODULINA; TIMUNOX

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.