Description
Cetrorelix was launched in Germany for the treatment of
female infertility. It is a decapeptidic analog of luteinizing hormone-releasing
hormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3,
6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelix
is an extremely potent and long acting gonadotrophin releasing hormone
(GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretion
immediately after administration. Moreover, it has a low histamine-releasing
potency. Cetrorelix will be the first LH-RH antagonist approved worldwide. In
several Phase III clinical trials, female patients receiving Cetrorelix had a
successful controlled ovulation thus avoiding a premature LH-surge. Cetrorelix
could be a first-choice in-vitro fertilization (IVF) treatment without the
complications of current controlled ovarian hyperstimulation protocols. Cetrorelix
is currently under clinical investigation for the treatment of diverse sex hormone
dependent disorders such as benign prostate hypertrophy, breast, ovarian or
prostate cancers and diverse gynaecological disorders.
Originator
Asta Medica (Germany)
Uses
Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.
Definition
ChEBI: A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-t
rosyl, N5-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH
antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Indications
Cetrorelix is used to delay your ovaries from releasing eggs too early (ovulation). It is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian stimulation.
Brand name
Cetrotide (Serono).
Side effects
Cetrorelix is usually administered by subcutaneous injection. The most common side effects include: pain, itching, swelling, discolouration or redness near the injection site; nausea and headache. Other possible effects may include: abdominal or stomach pain, reduced urine output, diarrhoea, indigestion, weight gain, pelvic pain, etc. Severe allergic reactions are rare.
