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141-78-6

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Identification

Name
Ethyl acetate
CAS
141-78-6
Synonyms
ABSOLUTE ALCOHOL
ACETIC ACID ETHYL ESTER
ACETIC ESTER
ACETIC ETHER
AKOS BBS-00004223
ALCOHOL
ALCOHOL C2
ALCOHOL, DENATURED
ALCOHOL, REAGENT, DENATURED
BASIC ORGANIC RAW
DENATURED ALCOHOL
etanol
ETHANOL
ETHANOL-10
ETHANOL-100
ETHANOL-15
ETHANOL-150
ETHANOL-20
ETHANOL-200
ETHANOL-25
EINECS(EC#)
205-500-4
Molecular Formula
C4H8O2
MDL Number
MFCD00003568
Molecular Weight
88.11
MOL File
141-78-6.mol

Chemical Properties

Appearance
Colorless liquid
Appearance
Ethyl acetate is a colorless liquid. Pleasant, fruity odor.
Appearance
Excipient.
mp 
−84 °C(lit.)

bp 
76.5-77.5 °C(lit.)

density 
0.902 g/mL at 25 °C(lit.)

vapor density 
3 (20 °C, vs air)

vapor pressure 
73 mm Hg ( 20 °C)

FEMA 
2414
refractive index 
n20/D 1.3720(lit.)

Fp 
26 °F

storage temp. 
2-8°C

Stability:
Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
Water Solubility 
80 g/L (20 ºC)
Detection Methods
GC
Merck 
14,3757
BRN 
506104
CAS DataBase Reference
141-78-6(CAS DataBase Reference)
NIST Chemistry Reference
Ethyl acetate(141-78-6)
Storage Precautions
Moisture sensitive
EPA Substance Registry System
141-78-6(EPA Substance)

Safety Data

Hazard Codes 
F,Xi,Xn,T
Risk Statements 
R11:Highly Flammable.
R36:Irritating to the eyes.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R10:Flammable.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R68/20/21/22:Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed .
Safety Statements 
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S33:Take precautionary measures against static discharges .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7:Keep container tightly closed .
S25:Avoid contact with eyes .
RIDADR 
UN 1173 3/PG 2

WGK Germany 
1

RTECS 
AH5425000


1
HazardClass 
3
PackingGroup 
II
HS Code 
29153100
Safety Profile
Potentially poisonous by ingestion. Toxicity depends upon alcohols in question, generally ethanol with methanol as a denaturant. A flammable liquid and dangerous fire hazard; can react vigorously with oxidzing materials. Moderate explosion hazard. See ETHANOL, METHYL ALCOHOL, and n-PROPYL ALCOHOL.
Hazardous Substances Data
141-78-6(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
A clear colorless liquid with a fruity odor. Flash point 24°F. Less dense than water. Vapors heavier than air.
Reactivity Profile
ETHYL ACETATE(141-78-6) is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with lithium aluminum hydride. ETHYL ACETATE(141-78-6) may also ignite with potassium tert-butoxide. ETHYL ACETATE(141-78-6) is incompatible with nitrates, strong alkalis and strong acids. ETHYL ACETATE(141-78-6) will attack some forms of plastics, rubber and coatings. ETHYL ACETATE(141-78-6) is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. . SOCl2 reacts with esters, such as ETHYL ACETATE(141-78-6), forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News 70(22):2.).
Air & Water Reactions
Highly flammable. Slightly soluble in water. This chemical is slowly hydrolyzed by moisture.
Hazard
Toxic by inhalation and skin absorption; irritant to eyes and skin. Flammable, dangerous fire and explosion risk, flammable limits in air 2.2–9%. Questionable carcinogen.
Health Hazard
Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness.
Potential Exposure
This material is used as a solvent for nitrocellulose and lacquer. It is also used in making dyes,flavoring and perfumery, and in smokeless powder manufacture
Fire Hazard
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Shipping
UN1173 Ethyl acetate, Hazard Class: 3; Labels: 3-Flammable liquid.
Incompatibilities
May form explosive mixture with air. Heating may cause violent combustion or explosion. Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminum hydride; oleum will hydrolyze on standing forming acetic acid and ethyl alcohol. This reaction is greatly accelerated by alkalies. Decomposes under influence of UV light, bases, and acids. Attacks aluminum and plastics.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≧100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Material Safety Data Sheet(MSDS)

Questions And Answer

organic ester compound
Ethyl Acetate is an organic ester compound with a molecular formula of C4H8O2 (commonly abbreviated as EtOAc or EA), appears as a colorless liquid. It is highly miscible with all common organic solvents (alcohols, ketones, glycols, esters), which make it a common solvent for cleaning, paint removal and coatings.
Ethyl acetate is found in alcoholic beverages, cereal crops, radishes, fruit juices, beer, wine, spirits etc. It has a fruity characteristic odor that is commonly recognized in glues, nail polish remover, decaffeinating tea and coffee, and cigarettes. Due to its agreeable aroma and low cost, this chemical is commonly used and manufactured in large scale in the world, as over 1 million tons annually.

ethyl acetate structure
Chemical Properties
Ethyl acetate (structure shown above) is the most familiar ester to many chemistry students and possibly the ester with the widest range of uses. Esters are structurally derived from carboxylic acids by replacing the acidic hydrogen by an alkyl or aryl group. Ethyl acetate itself is a colourless liquid at room temperature with a pleasant "fruity" smell, b.p. 77°C.
Ethyl acetate
Ethyl acetate has many uses, such as artificial fruit essences and aroma enhancers, artificial flavours for confectionery, ice cream and cakes, as a solvent in many applications (including decaffeinating tea and coffee) for varnishes and paints (nail varnish remover), and for the manufacture of printing inks and perfumes.
Purification and water removal methods
Ethyl acetate generally has a content of 95% to 98% containing a small amount of water, ethanol and acetic acid. It can be further purified as following: add 100mL of acetic anhydride into 1000mL of ethyl acetate; add 10 drops of concentrated sulfuric acid, heat and reflux for 4h to remove impurities such as ethanol and water, and then further subject to distillation. Distillate is oscillated by 20~30g of anhydrous potassium carbonate and further subject to re-distillation. The product has a boiling point of 77 °C and purity being over 99%.
Uses
Industry
Applications
Role/Benefit
Flavor and essence
Food flavor
Used largely to prepare bananas, pears, peaches, pineapple and grape scent food flavors, etc
Alcoholic essence
Used slightly as fragrance volatile
Perfume essence
Used slightly as fragrance volatile
Chemical manufacture
Production of acetamide, acetyl acetate, methyl heptanone, etc
Organic chemical raw materials
Production of organic acid
Extracting agent
Laboratory
Dilution and extraction
Supply excellent dissolving capacity
Chromatographic analysis
Standard material
Column chromatography and extractions
Main component of mobile phase
Reaction solvent
Be prone to hydrolysis and transesterification
Chemical analysis
Thermometer calibration for sugar separation
 Standard material
Determination of bismuth, boron, gold, molybdenum, platinum and thallium
Solvent
Entomology
Insect collecting and study
Used as effective asphyxiant to kill the collected insect quickly without destroying it
Textile industry
Cleaning agent
Supply excellent dissolving capacity
Printing
Flexographic and rotogravure printing
Dissolve the resin, control the viscosity and modify the drying rate
Electronics industry
Viscosity reducer
Reduce the viscosity of resins used in photoresist formulations
Paint manufacture
Solvent
Dissolve and dilute the paints
Health & personal care products
The formulation of nail polish, nail polish removers and other manicuring products
Supply excellent dissolving capacity
Pharmaceutical
Medicine manufacturing
Extraction agent; intermediate
Cosmetics
Aroma enhancer
In perfume to enhance aroma
Others
Tanning extracts
Used for desulfurization of tanning, cigarette materials, oil field drilling, metal flotation, descaling, etc
Production of adhesive
Solvent
Extract many compounds (phosphorus, cobalt, tungsten, arsenic) from aqueous solution
Extracting agent

Production
Industrial production of ethyl acetate is mainly classified into three processes.

The first one is a classical Fischer esterification process of ethanol with acetic acid in presence of acid catalyst. This process needs acid catalyst2 such as sulphuric acid, hydrochloride acid, ptoluene sulfonic acid etc. This mixture converts to the ester in about 65% yield at room temperature. 
CH3CH2OH + CH3COOH ↔ CH3COOC2H5 + H2O
The reaction can be accelerated by acid catalysis and the equilibrium can be shifted to the right by removal of water.

The second one is Tishchenko Reaction of acetaldehyde using aluminium triethoxide as a catalyst. In Germany and Japan, most ethyl acetate is produced via the Tishchenko process. 
2 CH3CHO → CH3COOC2H5
This method has been proposed by two different routes; (i) dehydrogenative process, which uses copper or palladium based catalyst and (ii) the oxidative one, which employs, PdO supported catalysts.

The third one, which has been recently commercialized, is addition of acetic acid to ethylene using clay and heteroploy acid7 as a catalyst. 
CH2= CH2 + CH3COOH → CH3COOC2H5 
The processes, however, have some disadvantages; both the conventional esterification and addition of acetic acid to ethylene need stock tanks and apparatus for several feed stocks. Moreover, they use acetic acid that causes apparatus corrosion. Although Teshchenko Reaction uses only one feed and it is a non-corrosive material, it is difficult to handle acetaldehyde because is not available outside of petrochemical industrial area.
In such circumstances, an improved process of ethyl acetate production is strongly desired.
Extinguishing agent
dry powder, dry sand, carbon dioxide, foam, and 1211 fire extinguishing agent
Professional standards
TWA 1400 mg/m³; STEL 2000 mg/m³

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