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Sermorelin acetate, also known as INN/Geref/Gerel, is a peptide analogue of growth hormone-releasing hormone (GHRH) used as a diagnostic agent to evaluate growth hormone (GH) secretion and diagnose growth hormone deficiency. It is a 29 amino acid polypeptide representing fragments 1-29 from endogenous human GHRH and is considered to be the shortest fully functional fragment of GHRH.

Sermorelin acetate is used as a diagnostic agent to assess growth hormone (GH) secretion. It is also used as doping agent in sports due to its correlation with increased growth of muscular and skeletal tissue. Sermorelin use is also hypothesized to improve deep rapid eye movement sleep.

Influence of growth hormone (GH) and GH-releasing factor on locomotor activity in rats DOI: 10.1016/0196-9781(93)90101-L
Comparison of GH-stimulation by GH-RH(1-29)NH2 and an agmatine29 GH-RH analog, after intravenous, subcutaneous and intranasal administration and after pulmonary inhalation in rats DOI: 10.1111/j.1399-3011.1993.tb00332.x
Potent agonists of growth hormone-releasing hormone Part I DOI: 10.1111/j.1399-3011.1992.tb00791.x
Synthesis and in vitro and in vivo activity of analogs of growth hormone-releasing hormone (GH-RH) with C-terminal agmatine DOI: 10.1111/j.1399-3011.1990.tb00988.x
Growth-hormone-releasing hormone DOI: 10.1093/clinchem/36.3.415