Phloroglucinol is a naturally occurring phenol that exhibits diverse biological activities.
1 Phloroglucinol protects V79-4 Chinese hamster lung fibroblast cells from oxidative stress and inhibits lipid peroxidation by scavenging reactive oxygen species (ROS).
2 It induces apoptosis in HT-29 human colon cancer cells and inhibits metastasis of BT549 and MDA-MB-231 human breast cancer cells.
3,4 Phloroglucinol protects primary neurons from β-amyloid-induced dendritic spine loss
in vitro and shortens the latency to find the platform in a Morris water maze test in an Alzheimer’s disease (AD) mouse model.
5 Phloroglucinol has been used to stain histological plant sections and in the synthesis of numerous natural products.
6,7,8 Phloroglucinol slows the frequency and decreases the amplitude of contraction in isolated rabbit and rat intestine at a concentration of 100 and 1 μM, respectively.
9 Formulations containing phloroglucinol have been used as antispasmodics.
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