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548-83-4

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Identification

Name
Galangin
CAS
548-83-4
Synonyms
3,5,7-trihydroxy-2-phenyl-chromen-4-one
3,5,7-TRIHYDROXYFLAVONE
GALANGIN
NORIZALPININ
3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
3,5,7-trihydroxy-flavon
3,5,7-trihydroxy-2-phenyl-4-benzopyrone
3,5,7-Trihydroxyflavone (Galangin)
3,5,7-Trihydroxyflavone,97%
GALANGIN hplc
GALANGIN WITH HPLC
2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Galengin
EINECS(EC#)
208-960-4
Molecular Formula
C15H10O5
MDL Number
MFCD00006833
Molecular Weight
270.24
MOL File
548-83-4.mol

Chemical Properties

Melting point 
214-215 °C(lit.)

mp 
214-215 °C(lit.)

Boiling point 
333.35°C (rough estimate)
density 
1.2319 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
room temp
pka
6.32±0.40(Predicted)
Merck 
14,4339
BRN 
272179
InChIKey
VCCRNZQBSJXYJD-UHFFFAOYSA-N
CAS DataBase Reference
548-83-4(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
WGK Germany 
3

RTECS 
LK9275500


10
HS Code 
29329990

Hazard Information

Chemical Properties
Yellow powder
Uses
CYP1A1 inhibitor, vasodilator
Uses
Galangin is a flavanoid found in Alpinia officinarum, galangal rhizome (Alpinia galanga) and in propolis. Galangin has been show to inhibit proliferation of estrogen receptor-positive MCF-7 human brea st cancer cells as well as delay of mammary tumorigenesis.
Definition
ChEBI: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively.
Anticancer Research
Galangin is a flavonol that is derived from Alpinia officinarum, a plant from the gingerfamily, grown in Southeast Asia. The extract from the rhizome suppresses cellproliferation of hepatocellular carcinoma cells (Su et al. 2013). ER stress is inducedby galangin as is evident by rise in concentration of cytosolic Ca2+ and other UPRtarget genes like CHOP, GRP 78 and GRP 94. The ER is a major storage site forintracellular calcium. Normal functioning of ER chaperones is disrupted by calciumexhaustion in ER which produces ER stress and hence activation of UPR (Hotamisligil2010; Mekahli et al. 2011). CHOP and 4-polybutyric acid siRNA, well-known ERstress inhibitor, substantially blocked stress induced by galangin in the HCC cell line.To sum up, ER stress is upregulated by galangin, inhibiting cancer cell proliferation,and galangin can prove to be an effective anticancer agent (Su et al. 2013).

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