Description
m-Chloroaniline
is used as an intermediate for pesticides, pharmaceuticals,
and dyes. It is produced by lowpressure
hydrogenation of 3-chloronitrobenzene
in the liquid phase with noble metal and/or noble
metal sulfide catalysts. The addition of metal oxides
to the reaction helps avoid dehalogenation.
The yield is approximately 98 %.
Chemical Properties
3-Chloroaniline is a clear pale yellow to brown liquid, which becomes darker during storage, insoluble in water, but soluble in ethanol, ether and acid solution.
Application
3-Chloroaniline is the intermediate of the herbicide chloraniline, and the intermediate of the pharmaceutical diuretic antihypertensive drug hydrochlorothiazide, and can be used to produce azo dyes.
3-Chloroaniline was the only aniline compound to increase plasmaALT/GPT activity at 48 h. It is employed in the bioaugmentation of activated sludge.
Uses
3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibito
rs.
Preparation
3-Chloroaniline is obtained by reducing 3-Nitrochlorobenzene with iron powder in the presence of ferrous sulfate.
General Description
Colorless to light amber liquid with a sweet odor.
Air & Water Reactions
Sensitive to prolonged exposure to air and light and tends to darken during storage. Insoluble in water.
Reactivity Profile
3-Chloroaniline(108-42-9) is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.
Fire Hazard
3-Chloroaniline is combustible.
Flammability and Explosibility
Nonflammable
