1-(3-Chlorophenyl)piperazine (also named as meta-Chlorophenylpiperazine (mCPP)) is a piperazine derivative and it is the major metabolite of Trazodone, Nefazodone, and Etoperidone. mCPP has stimulant and hallucinogenic properties. Pharmacologically, mCPP acts as a serotonin receptor agonist, which leads to antidepressant and anxiolytic properties, as well as hallucinogenic side effects. It was developed in the late 1970s for scientific research. Since mid-2000s, it is sold as a designer drug. mCPP can be sold as “legal Ecstasy” or as a “legal high” or “Ecstasy” itself. Nevertheless, mCPP is abused by users seeking Ecstasy-like effects. The toxic effects reported for mCPP include nausea, hallucinations, headache and most frequently, anxiety.
