108-10-1

A clear colorless liquid with a pleasant odor. Flash point 73°F. Less dense than water. Vapors heavier than air.

METHYL ISOBUTYL KETONE(108-10-1) is incompatible with caustic soda and other strong alkalis, hydrochloric acid, sulfuric acid and other strong inorganic acids, amines and oxidizing agents such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. METHYL ISOBUTYL KETONE(108-10-1) reacts violently with potassium tert-butoxide. METHYL ISOBUTYL KETONE(108-10-1) reacts vigorously with reducing materials. .

Highly flammable. This chemical is sensitive to air (may form explosive peroxides). Slightly soluble in water.

Flammable, dangerous fire risk, explosivelimits in air 1.4–7.5%. Avoid ingestion and inhala-tion. Upper respiratory tract irritant, dizziness, andheadache. Possible carcinogen.

Vapor causes irritation of eyes and nose; high concentrations cause anesthesia and depression. Liquid dries out skin and may cause dermatitis; irritates eyes but does not injure them.

MIBK is used as a solvent; a denaturant; and as an extractant; in the manufacture of methyl amyl alcohol; as a solvent in paints, varnishes, and lacquers; as an alcohol denaturant; as a solvent in uranium extraction from fission products.

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit

UN1245 Methyl isobutyl ketone, Hazard Class: 3; Labels: 3-Flammable liquid.

Able to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide; strong acids; aliphatic amines; reducing agents

4-Methyl-2-pentanone has a pleasant odor. May be prepared by hydrogenation of mesityl oxide over Ni at 160 - 190°C; also by oxidation of methyl isobutyl carbinol.

4-Methyl-2-pentanone has a fruity, ethereal, spicy (on dilution) odor.

Methyl isobutyl ketone (MIBK) is a colorless liquid with a pleasant, sweet, fruity odor. The odor threshold can be as low as 0.10 ppm. It is 2% soluble in water by weight and with several other organic solvents. The lower explosive limit is 1.2% and the upper explosive limit is 8.0% at 200 °F. Methyl isobutyl ketone may be incompatible with strong oxidizers and potassium tert-butoxide.

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.

Clear, colorless, watery liquid with a mild, pleasant odor. Odor threshold concentration is 47 ppb_v (Leonardos et al., 1969). Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m³ (100 ppb_v) and 1.1 mg/m³ (270 ppb_v), respectively (Hellman and Small, 1974).

Reported found in orange and lemon juice, grape; vinegar, baked potato, papaya, ginger, wheat bread, cheeses, milk, cooked egg, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushroom, trassi, sesame seed, buckwheat, wort, elder flower, Bourbon vanilla, clary and red sage, crab, clam and Chinese quince.

In paints, glues, and cleaning agents; used in the plastic and petrol industries

Methyl isobutyl ketone (hexone, isobutyl methyl ketone, 4-methyl-2-pentanone) is an organic solvent similar in structure and use to methyl butyl ketone. In addition to its use as a solvent for paints, lacquers, and varnishes, methyl isobutyl ketone is used in extraction processes and as a denaturant for rubbing alcohol. Methyl isobutyl ketone is also used as a synthetic flavoring in some varieties of rum, candy, and cheese. Unlike methyl butyl ketone, methyl isobutyl ketone has not been found to occur naturally.

MIBK is used as a solvent for gums, resins,nitrocellulose and cellulose ethers, and various fats, oils, and waxes.

ChEBI: Methyl isobutyl ketone is a ketone.

By hydrogenation of mesityl oxide over Ni at 160 to 190°C; also by oxidation of methyl isobutyl carbinol.

Methyl isobutyl ketone can be manufactured by two processes . The first is a mixed ketone process where MiBK, diisobutyl ketone, and acetone are coproduced in a single reaction using isopropanol as a starting material. The second method is used to produce the majority of MiBK and involves a three-step reaction sequence in which diacetone alcohol and mesityl oxide are formed as intermediates.

Detection: 240 to 640 ppb

Taste characteristics at 25 ppm: sweet, ethereal, banana and fruity with dairy nuances

Journal of the American Chemical Society, 100, p. 5437, 1978 DOI: 10.1021/ja00485a031
Tetrahedron Letters, 36, p. 2285, 1995 DOI: 10.1016/0040-4039(95)00191-E
Tetrahedron, 37, p. 3073, 1981 DOI: 10.1016/S0040-4020(01)98839-8

Highlyflammable

Reactivity with Water No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

The National Toxicology Program conducted cancer bioassays by exposing groups of 50 male and 50 female F344 rats and B6C3F1 mice to MiBK vapor at 0, 450, 900, or 1800 ppm 6h/day, 5 days/ week for 2 years. Survival and body weight gain were decreased in male rats at 1800 ppm. Body weight gain was also decreased in male rats at 900 and in female mice at 1800ppm. A higher incidence of mineralization of the renal papilla was observed in male rats at all MiBK exposure levels. Chronic progressive nephropathy (CPN) and the incidences of adenoma and adenoma or carcinoma (combined) were increased for the male 1800 ppm exposure group. The severity of CPN and renal tubular hyperplasia was increased in all male rat exposure groups. An uncertain increase in mononuclear cell leukemia, adrenal medulla hyperplasia, and a positive trend for increases in benign or malignant pheochromocytomas (combined) were reported for the 1800 ppm male group. The NTP considered that there was some evidence of carcinogenic activity in male rats based on increased incidences of renal tubule neoplasms.
None of the rodent bioassay results were considered clear evidence of carcinogenicity by NTP.

Biological. Bridié et al. (1979) reported BOD and COD values of 2.06 and 2.16 g/g using filtered effluent from a biological sanitary waste treatment plant. These values were determined using a standard dilution method at 20 °C and stirred for a period of 5 d. Heukelekian and Rand (1955) reported a 5-d BOD value of 1.51 g/g which is 55.5% of the ThOD value of 2.72 g/g.
Photolytic. When synthetic air containing gaseous nitrous acid and 4-methyl-2-pentanone was exposed to artificial sunlight (λ = 300–450 nm), photooxidation products identified were acetone, peroxyacetal nitrate, and methyl nitrate (Cox et al., 1980). In a subsequent experiment, the OHinitiated photooxidation of 4-methyl-2-pentanone in a smog chamber produced acetone (90% yield) and peroxyacetal nitrate (Cox et al., 1981). Irradiation at 3130 ? resulted in the formation of acetone, propyldiene, and free radicals (Calvert and Pitts, 1966).
Second-order photooxidation rate constants for the reaction of 4-methyl-2-butanone and OH radicals in the atmosphere are 1.4 x 10^-10, 1.42 x 10^-10, and 1.32 x 10^-10 cm³/molecule?sec at 295, 299, and 300 K, respectively (Atkinson, 1985). The atmospheric lifetime was estimated to be 1–5 d (Kelly et al., 1994).
Photolytic. Cox et al. (1980) reported a rate constant of 1.24 x 10^-11 cm³/molecule?sec for the reaction of gaseous 4-methyl-2-pentanone with OH radicals based on a value of 8 x 10^-12 cm³/molecule?sec for the reaction of ethylene with OH radicals.
Chemical/Physical. 4-Methyl-2-pentanone will not hydrolyze in water because it does not contain a hydrolyzable functional group (Kollig, 1993).

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Methylisobutyl ketone must be stored to avoid contact with strongoxidizers because violent reactions occur. Store in tightlyclosed containers in a cool, well-ventilated area away fromheat, sparks, and flames. Sources of ignition, such as smoking and open flames, are prohibited where methyl isobutylketone is used, handled, or stored in a manner that couldcrate a potential fire or explosion hazard. Metal containersinvolving the transfer of 5 gallons or more of methyl isobutyl ketone should be grounded and bonded. Drums must beequipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofmethyl isobutyl ketone.

Reflux the ketone with a little KMnO4, wash it with aqueous NaHCO3, dry with CaSO4 and distil it. Acidic impurities are removed by passage through a small column of activated alumina. [Beilstein 1 IV 3305.]