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Name 2-Butanone
CAS 78-93-3
EINECS(EC#) 201-159-0
Molecular Formula C4H8O
MDL Number MFCD00011648
Molecular Weight 72.11
MOL File 78-93-3.mol

Chemical Properties

2-Butanone is a stable, highly flammable chemical. It is incompatible with oxidising agents, bases, and strong reducing agents. It is a colourless liquid with a sharp, sweet odour. 2-Butanone is produced in large quantities. It is used as a solvent and nearly half of its use is in paints and other coatings because it will quickly evaporate into the air and it dissolves many substances. It is also used in glues and as a cleaning agent.
Appearance MEK is a clear, colorless liquid. Fragrant, mint-like, moderately sharp odor.
Melting point  -87 °C (lit.)
Boiling point  80 °C (lit.)
density  0.806
vapor density  2.49 (vs air)
vapor pressure  71 mm Hg ( 20 °C)
FEMA  2170
refractive index  n20/D 1.379(lit.)
Fp  26 °F
storage temp.  2-8°C
solubility  Miscible with acetone, ethanol, benzene, ether (U.S. EPA, 1985), and many other solvents, particularly ketones and aldehydes
form  Solution
pka 14.7 (quoted, Riddick et al., 1986)
color  Colorless
Odor Sweet/sharp odor detectable at 2 to 85 ppm (mean = 16 ppm)
PH pH(1+4, 25℃):6.0~7.0
Relative polarity 0.327
Stability: Stable. Highly flammable. Incompatible with oxidizing agents, bases, strong reducing agents. Protect from moisture.
explosive limit 1.8-11.5%(V)
Odor Threshold 0.44ppm
Odor Type ethereal
Water Solubility  290 g/L (20 ºC)
JECFA Number 278
Merck  14,6072
BRN  741880
Henry's Law Constant 23.0 at 50.00 °C, 34.1 at 60.00 °C, 50.6 at 70.00 °C, 70.4 at 80.00 °C (headspace-GC, Hovorka et al., 2002)
Dielectric constant 18.5(20℃)
Exposure limits TLV-TWA, PEL 590 mg/m3 (200 ppm) (ACGIH, OSHA); STEL 885 mg/m3 (300 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).
LogP 0.3 at 40℃
CAS DataBase Reference 78-93-3(CAS DataBase Reference)
NIST Chemistry Reference 2-Butanone(78-93-3)
EPA Substance Registry System 78-93-3(EPA Substance)

Safety Data

Hazard Codes  F,Xi,T
Risk Statements 
R11:Highly Flammable.
R36:Irritating to the eyes.
R66:Repeated exposure may cause skin dryness or cracking.
R67:Vapors may cause drowsiness and dizziness.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
Safety Statements 
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
RIDADR  UN 1193 3/PG 2
WGK Germany  1
RTECS  EL6475000
Autoignition Temperature 516 °C
HazardClass  3
PackingGroup  II
HS Code  29141200
storage 2-Butanone should be protected from moisture.
Precautions 2-Butanone vapor and air mixtures are explosive. It reacts violently with strong oxidants and inorganic acids causing fi re and explosion hazard.
Safety Profile
Moderately toxic by ingestion, skin contact, and intraperitoneal routes. Human systemic effects by inhalation: conjunctiva irritation and unspecified effects on the nose and respiratory system. An experimental teratogen. A strong irritant. Human eye irritation @ 350 ppm. Affects peripheral nervous system and central nervous system. Highly flammable liquid. Reaction with hydrogen peroxide + nitric acid forms a heatand shock-sensitive explosive product. Ignition on contact with potassium tert-butoxide. Mixture with 2- propanol will produce explosive peroxides during storage. Vigorous reaction with chloroform + alkali. Incompatible with chlorosulfonic acid, oleum. To fight fire, use alcohol foam, CO2, dry chemical. Used in production of drugs of abuse. When heated to decomposition it emits acrid smoke and fumes.
Hazardous Substances Data 78-93-3(Hazardous Substances Data)
LD50 orally in rats: 6.86 ml/kg (Smyth)
IDLA 3,000 ppm

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