General Description
A clear colorless liquid with the odor of fingernail polish. Flash point 45°F. Less dense than water and soluble in water. Hence floats on water. Density 0.809 g/cm3. Vapors heavier than air.
Reactivity Profile
METHYL PROPYL KETONE(107-87-9) is incompatible with oxidizing agents, strong bases and reducing agents. Reacts violently with bromine trifluoride .
Air & Water Reactions
Highly flammable. Soluble in water.
Hazard
Flammable, dangerous fire risk, explosivelimits in air 1.6–8.2%. Eye irritant and affects pul-monary function.
Health Hazard
Exposure can cause irritation of eyes, nose and throat.
Potential Exposure
MPK is used as a solvent; as a
synthetic food flavoring agent; and in organic synthesis;
as a solvent replacement for diethyl ketone and acetone.
First aid
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit
Shipping
UN1249 Methyl propyl ketone, Hazard Class: 3;
Labels: 3-Flammable liquid.
Incompatibilities
Ketones are incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, epoxides, nitrated amines,
azo, diazo, azido compounds, carbamates, organic cyanates.
Attacks some plastics
Chemical Properties
2-Pentanone has an ethereal, fruity odor.
Chemical Properties
colourless liquid
Chemical Properties
MPK is a colorless to water-white liquid with
a strong odor resembling acetone and ether.
Waste Disposal
Dissolve or mix the material
with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber. All
federal, state, and local environmental regulations must be
observed.
Physical properties
Clear, colorless, very flammable liquid with a characteristic, pungent odor. An odor threshold
concentration of 20 ppbv was determined by a triangular odor bag method (Nagata and Takeuchi,
1990). Cometto-Mu?iz et al. (2000) reported nasal pungency threshold concentration ranging from
approximately 500 to 3,200 ppm.
Occurrence
Reported found in wood spirit; also present in Ananas sativus; a few banana species, grapevines and some
citrus fruits. Also reported found in over 120 foods and beverages including fresh apple, papaya, fresh blackberry, vinegar, wheaten
bread, other types of bread, Swiss cheese, Camembert cheese, cheddar cheese, other cheeses, white wine, unprocessed rice, water
yam, apricot, orange juice, guava, grapes, pear, pineapple, strawberry, asparagus, carrot, celery, peas, tomato, butter, yogurt, cream,
milk powder, buttermilk, boiled egg, caviar, raw fish, cooked chicken and beef, pork fat, pork liver, hop oil, beer, cognac, rum,
bourbon whiskey, white wine, cocoa, coffee, roasted filberts and peanuts, peanut oil, potato chips, oat flakes, honey, soybean, passion
fruit, plum, beans, mushroom, starfruit, trassi, mango, globe artichoke, rice, soursop, malt, loquat, endive, shrimp, crab, lamb’s
lettuce and cape gooseberry.
Application
2-Pentanone is a flavoring agent that is a clear liquid, colorless, with flowery odor. it is miscible in alcohol and ether and soluble in water. it is obtained by chemical synthesis. it is also termed methyl propyl ketone. Methyl propyl ketone (MPK) is used as a solvent, substitute for diethyl ketone, in organic synthesis.
Definition
ChEBI: A pentanone carrying an oxo substituent at position 2.
Preparation
By dry distillation of a mixture consisting of calcium acetate and calcium butyrate; also by oxidation of sodium or ammonium
n-caproate with H2O2.
Production Methods
MPK can be manufactured by oxidation of 2-pentanol, from
ethylene and methyl acetoacetate, or by distillation of a
mixture of calcium acetate and calcium butyrate. Commercial
purity can be 90% MPK; however, some commercial
materials are a mixture of MPK and diethylketone with small
amounts of sec-amyl acetate.
Aroma threshold values
Detection: 70 ppb
Taste threshold values
Taste characteristics at 25 ppm: sweet, fruity and banana-like with a fermented nuance.
Fire Hazard
Flammable liquid; flash point (closed cup)
7°C (45°F); vapor density 3 (air = 1); vapor
pressure 27 torr at 20°C (68°F); the vapor can
travel a considerable distance to an ignition
source and flash back; autoignition temperature 452°C (846°F); fire- extinguishing agent:
“alcohol” foam; a water spray may be used to
absorb the heat and flush the spill away from
exposures. MPK forms an explosive mixture
with air in the range 1.5–8.2% by volume
of air. Heating with oxidizers can cause an
explosion (U.S. EPA 1988).
Biochem/physiol Actions
Taste at 20 ppm
Environmental Fate
Chemical/Physical. Atkinson et al. (2000) studied the gas-phase reaction of 2-pentanone with
OH radicals in purified air at 25 °C and 740 mmHg. A relative rate constant of 4.56 x 10-12
cm3/molecule·sec was calculated for this reaction. Reaction products identified by GC, FTIR, and
atmospheric pressure ionization tandem mass spectroscopy were (with respective molar yields)
were: formaldehyde, 1.03; acetaldehyde, 0.51; propanal, 0.19; 2,4-pentanedione, 0.12; and
molecular weight 147 organic nitrates.
At an influent concentration of 1.0 g/L, treatment with GAC resulted in an effluent
concentration of 305 mg/L. The adsorbability of the GAC was 139 mg/g carbon (Guisti et al.,
1974).
Will not hydrolyze in water because 3-pentanone does not contain a hydrolyzable group.
storage
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Methylpropyl ketone must be stored to avoid contact with oxidizers since violent reactions occur. Store in tightly closedcontainers in a cool, well-ventilated area away from heat,sparks, or flame. Sources of ignition, such as smoking andopen flames, are prohibited where methyl propyl ketone ishandled, used, or stored. Metal containers used in the transfer of 5 gallons or more of methyl propyl ketone should begrounded and bonded. Drums must be equipped with selfclosing valves, pressure vacuum bungs, and flame arresters.Use only nonsparking tools and equipment, especially whenopening and closing containers of methyl propyl ketone.Wherever methyl propyl ketone is used, handled, manufactured, or stored, use explosion-proof electrical equipmentand fittings.
Purification Methods
Purify the ketone by refluxing it with a little KMnO4, dry it with CaSO4 and distil it. It can be converted to its bisulfite addition compound by shaking with excess saturated aqueous NaHSO3 at room temperature, cooling to 0o, filtering, washing with diethyl ether and drying. Steam distillation of the adduct gives a distillate from which the ketone is recovered, washed with aqueous NaHCO3 and distilled water, dried (K2CO3) and fractionally distilled. [Waring & Garik J Am Chem Soc 78 5198 1956, Beilstein 1 IV 3271.]
