Supplier Related Products Identification Chemical Properties Raw materials And Preparation Products Safety Data Questions And Answer
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104458-24-4

Supplier Related Products Identification Chemical Properties Raw materials And Preparation Products Safety Data Questions And Answer

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Identification

Name
2-Aminoethylmethylsulfone hydrochloride
CAS
104458-24-4
Synonyms
2-MESYLETHAN-1-AMINE HYDROCHLORIDE
2-(Methylsulfonyl)-ethanamine hydrochloride
2-(Methylsulfonyl)Ethylamine HCl
2-(methylsulfonyl)ethylamine hydrochloride
Molecular Formula
C3H10ClNO2S
MDL Number
MFCD03840162
Molecular Weight
159.63
MOL File
104458-24-4.mol

Chemical Properties

CAS DataBase Reference
104458-24-4(CAS DataBase Reference)

Raw materials And Preparation Products

Safety Data

HS Code 
29211990

Questions And Answer

Description
Lapatinib is a new drug targeted for the treatment of breast cancer developed by GlaxoSmithKline, which was approved for marketing by the US Food and Drug Administration on March 13, 2007. The currently approved indications are advanced mastocarcinoma treated with lapatinib and capecitabine or metastatic breast cancer, and breast cancer patients must be treated first in other first-class drugs. Its trade name is Tykerb in the United States. On December 14, 2007, the European Medicines Agency (EMEA) approved for marketing of lapatinib in Europe, and the trade name is Tyverb. Breast cancer molecular targeted therapy is the treatment for oncogene related with occurrence and development of breast cancer, and for its related expression product. Molecular targeted drugs control the changes of gene expression in the cell through blocking signal transduction of tumor cell or related cell, thereby inhibiting or killing tumor cells.
Lapatinib is a small molecule epidermal growth factor tyrosine kinase inhibitor orally. Clinical trials have shown that lapatinib has a very good clinical effect in patients with HER2 breast cancer who have been resistant to Roche's Herceptin. In vitro, the inhibitory effect of lapatinib on the growth of Her-2 overexpressing breast cancer cell lines was significant. Lapatinib is also highly effective in the Phase I clinical trial of Her-2 overexpression in advanced breast cancer and has no cross-resistance with Herceptin (trastuzumab). Unlike Herceptin (trastuzumab), its structure is small molecules, so it could get through the blood-brain barrier, thereby having a certain therapeutic effect for breast cancer brain metastases.
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