Warfarin sodium

Химические свойства

Colorless solid

Использование

Warfarin Sodium (Crystalline Clathrate) is used for pharmaceutical care for patients with chronic heart failure and renal dysfunction.

Общее описание

Slightly bitter crystalline powder. An anticoagulant used as a rodenticide.

Профиль реактивности

A coumarin derivative, a lactone. Lactones are similar to esters reactive chemistries.

Угроза здоровью

Warfarin sodium is highly toxic orally in humans.

Пожароопасность

When heated to decomposition, Warfarin sodium emits toxic fumes of sodium oxide.

Клиническое использование

By virtue of its great potency, warfarin sodium at firstwas considered unsafe for use in humans and was used veryeffectively as a rodenticide, especially against rats. At theproper dosage level, however, it can be used in humans, especiallythrough the intravenous route.

Профиль безопасности

Poison to humans by ingestion. Experimental poison by ingestion and intravenous routes. Human systemic effects by ingestion: dermatitis. Human reproductive effects by ingestion: fetotoxicity, abnormal condition of newborn at birth, other newborn physical effects, and teratogenic effects includmg developmental abnormalities of the eye and ear, craniofacial area, skin and appendages, musculoskeletal system, cardiovascular system, and gastrointestinal system of the fetus. ,4n experimental teratogen. Other experimental reproductive effects. Mutation data reported. An anticoagulant drug. When heated to decomposition it emits toxic fumes of Na2O.