ТРИЭТИЛЦИТРАТ

Химические свойства

Triethyl citrate is a clear, viscous, odorless, and practically colorless, hygroscopic liquid.

Вхождение

Reported found in Morello cherry, sour cherry and red currant. Also reported found in raw cabbage and white wine.

Использование

Triethyl Citrate is a sequestrant that is an oily liquid, slightly solu- ble in water. it is found in lemon drinks.

Подготовка

By esterification of ethyl alcohol with citric acid.

Методы производства

Triethyl citrate is prepared by the esterification of citric acid and ethanol in the presence of a catalyst.

Общее описание

Triethyl citrate is a safe direct food additive.

Фармацевтические приложения

Triethyl citrate and the related esters acetyltriethyl citrate, tributyl citrate, and acetyltributyl citrate are used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.
Triethyl citrate is also used as a direct food additive for flavoring, for solvency, and as a surface active agent.

Профиль безопасности

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion and inhalation. Combustible liquid when exposed to heat or flame. To fight fire, use dry chemical, CO2. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS and CITRIC ACID.

Безопасность

Triethyl citrate is used in oral pharmaceutical formulations and as a direct food additive. It is generally regarded as a nontoxic and nonirritant material. However, ingestion of large quantities may be harmful.
LD50 (mouse, IP): 1.75 g/kg
LD50 (rat, IP): 4 g/kg
LD50 (rat, oral): 5.9 g/kg
LD50 (rat, SC): 6.6 g/kg

хранилище

Triethyl citrate should be stored in a closed container in a cool, dry location. When stored in accordance with these conditions, triethyl citrate is a stable product.

Несовместимости

Triethyl citrate is incompatible with strong alkalis and oxidizing materials.

Регуляторный статус

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.