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Ломефлоксацин
- английское имяLomefloxacin
- CAS №98079-51-7
- CBNumberCB2723615
- ФормулаC17H19F2N3O3
- мольный вес351.35
- EINECS619-317-6
- номер MDLMFCD00242673
- файл Mol98079-51-7.mol
химическое свойство
Температура плавления | 239-240 C |
Температура кипения | 542.7±50.0 °C(Predicted) |
плотность | 1.342±0.06 g/cm3(Predicted) |
температура хранения | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
растворимость | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
пка | -0.25±0.20(Predicted) |
форма | Solid |
цвет | Pale Yellow to Light Yellow |
Справочник по базе данных CAS | 98079-51-7(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
FDA UNII | L6BR2WJD8V |
Код УВД | J01MA07,S01AE04 |
Система регистрации веществ EPA | 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (98079-51-7) |
Коды опасности | Xn,Xi |
Заявления о рисках | 22-36/37/38 |
Заявления о безопасности | 26-36 |
WGK Германия | 3 |
RTECS | VB1997500 |
кода HS | 29419000 |
Токсичность | LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh) |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
H332:Вредно при вдыхании.
H312:Вредно при попадании на кожу.
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оператор предупредительных мер
P280:Использовать перчатки/ средства защиты глаз/ лица.
Ломефлоксацин химические свойства, назначение, производство
Описание
Lomefloxacin is a once-daily, third-generation quinolone antibiotic useful in the treatment of bacterial infections. The new fluorinated quinolone does not interfere with the metabolism of theophylline; it is efficacious against pathogens resistant to cephalosporins, penicillins and aminoglycosides.Химические свойства
colorless NeedlesИспользование
Anti bacterial.Определение
ChEBI: A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.Фармацевтические приложения
A difluoropiperazinyl quinolone formulated as the hydrochloride salt for oral administration. The in-vitro activity is very similar to that of norfloxacin . It is active against Enterobacteriaceae and fastidious Gram-negative bacilli, including L. pneumophila. Activity against Campylobacter spp., Ps. aeruginosa, Acinetobacter and Chlamydia spp. is poor. It has reduced activity against staphylococci and poor activity against streptococci, L. monocytogenes, anaerobes and Mycobacterium spp.A 400 mg oral dose achieves a concentration of 3–5 mg/L after 1–1.5 h. In escalating oral doses of 100, 400 and 800 mg to volunteers, the AUC was essentially proportional to the dosage, the mean plasma concentrations following 100, 400 and 800 mg doses being approximately 1.1, 4.7 and 7.5 mg/L, respectively.
Several metabolites have been described, accounting for <5% of the oral dose. Elimination occurs principally via the kidneys and 50–70% of a dose appears in the urine over 24 h. In patients with impaired renal function given 400 mg orally, the apparent elimination half-life ranged from 8 to 44 h, depending on the degree of renal failure. Non-renal clearance was also impaired, but there was no significant change in other pharmacokinetic parameters. The daily dosage (400 mg) should be reduced to 280 mg when the creatinine clearance falls below 30 mL/min. Hemodialysis has no effect on the plasma concentration. The effect of lomefloxacin on the plasma concentration of theophylline is clinically insignificant and no dosage adjustment is required.
The main adverse event is phototoxicity; other adverse events (mainly diarrhea, abdominal pain, skin reactions, dizziness, headache and insomnia) occur in about 10% of patients.
It is chiefly used in urinary tract infection, but is no longer widely available.
Клиническое использование
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (Maxaquin) is adifluorinated quinolone with a longer elimination half-life(7–8 hours) than other members of its class. It is the onlyquinolone for which once-daily oral dosing suffices. The oralbioavailability of lomefloxacin is estimated to be 95% to98%. Food slows, but does not prevent, its oral absorption.The extent of biotransformation of lomefloxacin is only about5%, and high concentrations of unchanged drug, rangingfrom 60% to 80%, are excreted in the urine. The comparativelylong half-life of lomefloxacin is apparently because ofits excellent tissue distribution and renal reabsorption and not because of plasma protein binding (only ~10%) or enterohepaticrecycling (biliary excretion is estimated to be ~10%).Lomefloxacin has been approved for two primary indications. First, it is indicated for acute bacterial exacerbations of chronic bronchitis caused by H. influenzae or Moraxella (Branhamella) catarrhalis, but not if Streptococcus pneumoniae is the causative organism. Second, it is used for prophylaxis of infection following transurethral surgery. Lomefloxacin also finds application in the treatment of acute cystitis and chronic urinary tract infections caused by Gram-negative bacilli.
Ломефлоксацин запасные части и сырье
сырьё
- Этанол
- 2,3,4-Trifluoroaniline
- 2-ETHOXY-MALONIC ACID DIETHYL ESTER
- АНГИДРИД УКСУСНОЙ КИСЛОТЫ
- N,N-Диметилформамид
- 2-метилпиперазин
- 1,2-дифенилэтана
- Ломефлоксацин гидрохлорид
- тетрафторбензол
- 1,2,3-трифтор-4-нитробензола
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Ломефлоксацин поставщик
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