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Ампициллин
- английское имяAmpicillin
- CAS №69-53-4
- CBNumberCB2247346
- ФормулаC16H19N3O4S
- мольный вес349.4
- EINECS200-709-7
- номер MDLMFCD00072036
- файл Mol69-53-4.mol
Температура плавления | 198-200 °C (dec.)(lit.) |
альфа | D23 +287.9° (c = 1 in water) |
Температура кипения | 201.8°C (rough estimate) |
плотность | 1.2794 (rough estimate) |
показатель преломления | 1.6320 (estimate) |
температура хранения | 2-8°C |
растворимость | NH4OH 1 M: 50 mg/mL, clear, colorless |
форма | solid |
цвет | White to Pale Yellow |
пка | 2.5 (COOH)(at 25℃) |
Растворимость в воде | 13.9g/L(25 ºC) |
Номер JECFA | 85 |
Мерк | 13,591 |
БРН | 1090925 |
Стабильность | Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents. |
ИнЧИКей | AVKUERGKIZMTKX-NJBDSQKTSA-N |
Справочник по базе данных CAS | 69-53-4(CAS DataBase Reference) |
FDA 21 CFR | 556.40 |
FDA UNII | 7C782967RD |
Словарь наркотиков NCI | Wymox |
Код УВД | J01CA01,J01CA51,S01AA19 |
МАИР | 3 (Vol. 50) 1990 |
Система регистрации веществ EPA | Ampicillin (69-53-4) |
Коды опасности | Xn,T |
Заявления о рисках | 36/37/38-42/43-61 |
Заявления о безопасности | 22-26-36/37-45-53 |
WGK Германия | 2 |
RTECS | XH8425000 |
F | 10-23 |
кода HS | 29212900 |
Банк данных об опасных веществах | 69-53-4(Hazardous Substances Data) |
Токсичность | LD50 oral in mouse: > 5gm/kg |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H317:При контакте с кожей может вызывать аллергическую реакцию.
H334:При вдыхании может вызывать аллергическую реакцию (астму или затрудненное дыхание).
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оператор предупредительных мер
P261:Избегать вдыхания пыли/ дыма/ газа/ тумана/ паров/ аэрозолей.
P272:Не уносить загрязненную спецодежду с места работы.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P284:Использовать средства защиты органовдыхания.
P302+P352:ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды.
P333+P313:При возникновении раздражения или покраснения кожи обратиться за медицинской помощью.
Ампициллин химические свойства, назначение, производство
Описание
Ampicillin is an antibacterial antibiotic from the α-aminobenzyl penicillin group, which differs from penicillin by the presence of an amino group that facilitates penetration through the outer membrane of some gram-negative bacteria.Ampicillin is Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. Ampicillin acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria.
Ampicillin is a β-lactam antibiotic within the penicillin family. As a member of this family, Ampicillin is susceptible to β-lactamase, which hydrolyzes the β-lactam ring. This broad spectrum antibiotic is effective against gram-positive, gram-negative bacteria and anaerobic bacteria. Ampicillin is widely used in cell culture as a selective agent. As an antibiotic, Ampicillin binds to penicillin binding proteins (PBPs) on a susceptible organism and Inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. After binding to the PBPs, Ampicilin acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and thereby prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.
Ampicillin sodium can be used as a selective agent in several types of isolation media. Ampicillin sodium is routinely used to select for cells containing the pcDNA3.1 and pEAK10 resistance plasmids in cell line A904L at an effective concentration of 50 μg/ml.
Химические свойства
Ampicillin in anhydrous form occurs as crystals.Использование
Labelled Ampicillin. Orally active, semi-synthetic antibiotic; structurally related to penicillin. Antibacterial.Определение
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.Общее описание
Ampicillin was synthesized by Beecham Research Laboratories in 1961 and evaluated for its anti-gram-negative activity by Rolinson et al.. It was the first semisynthetic penicillin showing strong activity against gramnegative bacilli. Although it is hydrolyzed by bacterial penicillinase, it is active against Escherichia coli, Shigella, Proteus mirabilis, and Haemophilus influenzae and is used very widely as an oral antibiotic. Ampicillin also is used by injection for serious infections.Контактные аллергены
Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.Профиль безопасности
Poison by intracerebral route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: fever, agranulocytosis, and other blood effects. An experimental teratogen. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NO, and SOx,.Возможный контакт
Used as an antibiotic.Перевозки
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.Несовместимости
May be incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.Утилизация отходов
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.Ампициллин запасные части и сырье
Ампициллин поставщик
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