Натрий формальдегидсульфоксилат дигидрат

Химические свойства

white crystalline powder

Использование

Pharmaceutic aid (preservative).

Методы производства

Sodium formaldehyde sulfoxylate is manufactured from sodium dithionate and formaldehyde in water.

Общее описание

Oxidation reation of hydroxymethanesulfinic acid with chlorite has been studied in the pH range 4-8. It is a sulfur-containing reducing agent.

Фармацевтические приложения

Sodium formaldehyde sulfoxylate is a water-soluble antioxidant and is generally used as the dihydrate. It is used in the formulation of injection products at a level of up to 0.1% w/v in the final preparation administered to the patient.

Безопасность

The toxicological properties of sodium formaldehyde sulfoxylate have not been fully investigated. However, it is used in the formulation of injection products at a level to 0.1% w/v in the final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by ingestion, and when heated to decomposition it emits toxic fumes of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg

хранилище

Store in well-closed, light-resistant containers at controlled room temperature (15–30℃).

Несовместимости

Sodium formaldehyde sulfoxylate is incompatible with strong oxidizing agents; it is decomposed by dilute acid.

Регуляторный статус

Included in the FDA Inactive Ingredients Database (parenteral products up to 0.1% via the IM, IV, and SC routes). Included in the Canadian List of Acceptable Non-medicinal Ingredients.