Алюминия калия сульфат

Химические свойства

white powder(s); absorbs atmospheric moisture [MER06]

Использование

Astringent (topical).

Определение

ChEBI: A metal sulfate composed of potassium, aluminium and sulfate ions in the ration 1:1:2.

Методы производства

Potassium alum is manufactured by treating bauxite with sulfuric acid and then potassium sulfate. Alternatively, aluminum sulfate is reacted with potassium sulfate.

Фармацевтические приложения

Potassium alum precipitates proteins and is a powerful astringent. The ability to precipitate proteins is utilized in the manufacture of vaccines, where purified proteins are coprecipitated with and adsorbed onto potassium alum.
Potassium alum is often included in preparations used as mouthwashes or gargles and in dermatological preparations, and it may be used as a topical hemostatic, either as a solid or as a solution. Intravesical instillation of potassium alum, typically as a 1% solution, has been used for hemorrhagic cystitis.

Безопасность

Potassium alum is often included in preparations used as mouthwashes or gargles and in dermatological preparations.
Large doses of potassium alum act as an irritant and may be corrosive; gum necrosis and gastrointestinal hemorrhage have occurred. Acute encephalopathy has been reported following bladder irrigation with alum solutions in the treatment of bladder hemorrhage. Anecdotal evidence suggests that this practice should be avoided for patients with renal insufficiency.

хранилище

Store in a cool, dry place in tightly closed containers. Stable under normal temperatures and pressures. When kept for a long time at 60–65°C (or over sulfuric acid) potassium alum dodecahydrate loses water, which is reabsorbed on exposure to air. It becomes anhydrous at about 200°C.

Несовместимости

Potassium alum is incompatible with strong oxidizing agents, aluminum, copper, steel, and zinc. When it is dispensed in powders with phenol, salicylates, or tannic acid, gray or green colors may be developed owing to traces of iron in the alum.

Регуляторный статус

GRAS listed. Included in the FDA Inactive Ingredients Database (vaginal; suppository). Included in medicines licensed in the UK.