ChemicalBook > Product Catalog > API > Synthetic Anti-infective Drugs > Antiseptics & Disinfectants Drugs > 2-Phenoxyethanol
2-Phenoxyethanol Chemical Properties
- Melting point:11-13 °C
- Boiling point:247 °C(lit.)
- Density 1.107 g/mL at 20 °C(lit.)
- vapor density 4.8 (vs air)
- vapor pressure 0.01 mm Hg ( 20 °C)
- FEMA 4620 | 2-PHENOXYETHANOL
- refractive index n
- Flash point:>230 °F
- storage temp. room temp
- solubility soluble, clear, colorless to very faintly yellow
- form Liquid
- color Clear colorless
- Specific Gravity1.109 (20/4℃)
- OdorFaint aromatic odor
- PH7 (10g/l, H2O, 23℃)
- PH Range7 at 10 g/l at 23 °C
- explosive limit1.4-9.0%(V)
- Water Solubility 30 g/L (20 ºC)
- Merck 14,7257
- BRN 1364011
- CAS DataBase Reference122-99-6(CAS DataBase Reference)
- NIST Chemistry Reference2-Phenoxyethanol(122-99-6)
- EPA Substance Registry SystemEthylene glycol monophenyl ether (122-99-6)
- Hazard Codes Xn,Xi
- Risk Statements 22-36-R36-R22
- Safety Statements 26-S26
- WGK Germany 1
- RTECS KM0350000
- Autoignition Temperature535 °C DIN 51794
- Hazard Note Irritant
- TSCA Yes
- HS Code 29094990
- Hazardous Substances Data122-99-6(Hazardous Substances Data)
- ToxicityLD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg
2-Phenoxyethanol Usage And Synthesis
- DescriptionPhenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
- Chemical Propertiesclear colorless liquid
- Chemical PropertiesPhenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.
- CharacteristicsPhenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.
- Usesphenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.
- UsesEthylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.
- UsesPhenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.
- UsesAntimicrobial preservative; also used topically in treatment of bacterial infections.
- Production MethodsPhenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.
- General DescriptionColorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.
- Air & Water ReactionsOxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.
- Reactivity Profile2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.
- Health HazardMay cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.
- Fire Hazard2-Phenoxyethanol is combustible.
- Pharmaceutical ApplicationsPhenoxyethanol is an antimicrobial preservative used in cosmetics
and topical pharmaceutical formulations at a concentration of
0.5–1.0%; it may also be used as a preservative and antimicrobial
agent for vaccines.Therapeutically, a 2.2% solution or 2.0%
cream has been used as a disinfectant for superficial wounds, burns,
and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,
- Industrial uses2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).
- Contact allergensPhenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.
- Safety ProfileModerately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.
- SafetyPhenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD50 (rabbit, skin): 5 g/kg
LD50 (rat, oral): 1.26 g/kg
- storageAqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.
- IncompatibilitiesThe antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).
- Regulatory StatusIncluded in the FDA Inactive Ingredients Database (topical
preparations). Included in nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.
2-Phenoxyethanol Preparation Products And Raw materials
- Phenethyl alcohol 2-Butoxyethyl acetate Ethanol,2,2'(dodecylimino)di,ethyl with polyethylene glycol Ethyleneamines Ethylene glycol diglycidyl ether 2-Methoxyethanol 2-Phenoxyethanol 3-Methoxybenzaldehyde Anisic acid 2-Butoxyethanol OCTYLPHENYLPOLYETHYLENE GLYCOL Polyethylene Ethyleneimine p-Anisaldehyde (Trifluoromethoxy)benzene Ethylene glycol diacetate ETHYLENE OXIDE Ethylene glycol
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