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Pamidronate disodium salt

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Pamidronate disodium salt Basic information
Pamidronate disodium salt Chemical Properties
  • Melting point:300 °C
  • storage temp. 2-8°C
  • solubility H2O: 28 mg/mL
  • form solid
  • color white
  • Merck 14,7003
  • CAS DataBase Reference57248-88-1(CAS DataBase Reference)
Safety Information
Pamidronate disodium salt Usage And Synthesis
  • DescriptionDisodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
  • Chemical PropertiesWhite Crystals
  • OriginatorHenkel (United Kingdom)
  • UsesA bisphosphonate antiresorptive agent; bone resorption inhibitor.
  • UsesPamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
  • UsesA farnesyl diphosphate synthase inhibitor
  • brand nameAredia (Novartis).
  • Veterinary Drugs and TreatmentsPamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.
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