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Basic information Description Safety Related Supplier
3-Chloro-2-methylpropene Basic information
3-Chloro-2-methylpropene Chemical Properties
  • Melting point:-80 °C (lit.)
  • Boiling point:71-72 °C (lit.)
  • Density 0.925 g/mL at 20 °C (lit.)
  • vapor density 3.12 (vs air)
  • vapor pressure 102 mm Hg ( 20 °C)
  • refractive index n20/D 1.427(lit.)
  • Flash point:9 °F
  • storage temp. 2-8°C
  • solubility H2O: insoluble
  • form Liquid
  • color Clear
  • explosive limit2.2-10.4%(V)
  • Water Solubility 0.5 g/L (20 ºC)
  • Merck 14,2148
  • BRN 878160
  • CAS DataBase Reference563-47-3(CAS DataBase Reference)
  • NIST Chemistry Reference1-Propene, 3-chloro-2-methyl-(563-47-3)
  • IARC2B (Vol. 63, 115) 2018
  • EPA Substance Registry System3-Chloro-2-methyl-1-propene (563-47-3)
Safety Information
3-Chloro-2-methylpropene Usage And Synthesis
  • Description3-Chloro-2-methylpropene is used as an intermediate to produce carbofuran, herbicides, plastics, pharmaceuticals and other organics. It is also used as an additive in textile and perfumes. It was used to study ring opening polymerization of oxirane derivatives using organotin phosphate condensate and cationic polymerization of 3-Chloro-2-methylpropene with AICI3 and AIBr3 as initiators. It is also the reactant for the synthesis of cyclobutanone.
  • Chemical Propertiesclear liquid
  • UsesIn organic synthesis.
  • Uses3-Chloro-2-methylpropene has been used as reactant in the synthesis of cyclobutanone. It is used as an intermediate in the production of plastics, pharmaceuticals and other organic chemicals.
  • Biological FunctionsMAC is a valuable index for clinical anesthesia, but it is seldom employed without taking other factors into consideration. For example, inhibiting movement in only 50% of patients is not acceptable. Consequently, if an inhalational agent were being used alone—that is, without the administration of other anesthetics or analgesic drugs—the anesthesiologist would employ a multiple of its MAC value to ensure immobility.MAC is frequently multiplied by a factor of 1.3 to achieve nearly 100% clinical efficacy. On the other hand, useful clinical results may be achieved with doses of anesthetics below MAC levels. For example, mild analgesia and amnesia often occur with doses of inhalational agents that are near 0.5 MAC. In this state, it may even be possible to communicate with patients intraoperatively, while their recall is limited.
  • Synthesis Reference(s)The Journal of Organic Chemistry, 46, p. 824, 1981 DOI: 10.1021/jo00317a041
  • General DescriptionA colorless to straw-colored liquid with a sharp penetrating odor. Less dense than water and insoluble in water. Flash point below 0°F. May be toxic by ingestion. Irritating to skin and eyes. Used to make plastics and pharmaceuticals.
  • Air & Water ReactionsHighly flammable. 3-Chloro-2-methylpropene may react with water at elevated temperatures. . Insoluble in water.
  • Reactivity Profile3-Chloro-2-methylpropene is sensitive to light. 3-Chloro-2-methylpropene can react vigorously with oxidizers. 3-Chloro-2-methylpropene is incompatible with strong bases. 3-Chloro-2-methylpropene may react with water at elevated temperatures. .
  • HazardIrritant; poison; anesthetic; questionable carcinogen; toxic.
  • Health HazardInhalation causes irritation of nose and throat. Contact of vapor or liquid with eyes causes irritation. Liquid irritates skin. Ingestion causes irritation of mouth and stomach.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. An irritant. Human mutation data reported. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderately explosive when exposed to heat or flame. Can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and ALLYL COMPOUNDS.
  • Carcinogenicity3-Chloro-2-methylpropene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
3-Chloro-2-methylpropene Preparation Products And Raw materials
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