3'-Ethoxy-5,6-dihydrospinosyn J is the major component in the second generation spinosyn family of bio-insecticides marketed as Spinetoram. 3'-Ethoxy-5,6-dihydrospinosyn J is a semi-synthetic compound prepared by selective ethylation and hydrogenation of Spinosyn J, itself a fermentation product from a biosynthetically blocked mutant of Saccharopolyspora spinosa. As an insecticide, 3'-ethoxy-5,6-dihydrospinosyn J is considered more potent, and to have earlier onset and longer duration of action than combinations of spinosyn A and D.
Spinetoram J is not manufactured through a single chemical synthesis but through a semi synthetic upgrade of natural spinosyns produced by Saccharopolyspora spinosa. The process begins with microbial fermentation, where a genetically modified strain is engineered to block a specific O methylation step, causing the organism to accumulate the precursor 5,6 dihydrospinosyn J. This fermentation product is then subjected to selective chemical modification, most notably 3′ O ethylation, to yield spinetoram J as one of the two active components of commercial spinetoram. The resulting semi synthetic molecule is purified to agrochemical grade and blended with spinetoram L to form the final insecticidal active ingredient.
Shows high residual, contact and ingestion activity. Nicotinic acetylcholine receptor (nAChR) channel blocker - site I
