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Difenoconazole

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Difenoconazole Basic information
Difenoconazole Chemical Properties
Safety Information
  • Hazard Codes Xn,N
  • Risk Statements 22-41-43-50-20/22
  • Safety Statements 26-36/37/39-61
  • RIDADR UN 3077 9 / PGIII
  • WGK Germany 3
  • RTECS XZ4380000
  • ToxicityLD50 in rats (mg/kg): 1453 orally; in rabbits: >2010 dermally (Ruess)
MSDS
Difenoconazole Usage And Synthesis
  • DescriptionDifenoconazole is a kind of triazole-type fungicide. It is a broad-spectrum triazole fungicide. It takes effect through acting as the inhibitor of sterol 14α-demethylase, blocking the biosynthesis of sterol. Through inhibiting the sterol biosynthesis process, it inhibits the mycelia growth and germination of pathogens by spores, ultimately suppressing the proliferation of fungi. Difenoconazole has been extensively used in a wide range of crops in many countries due to its ability to control various fungal diseases. It is also one of the most important and widely-used pesticides for disease control in rice.
  • UsesAgricultural fungicide.
  • UsesPestanal is an fungicide that exhibits a broad spectrum of activities against a wide variety of fungi including members of the Aschomycetes, Basidomycetes and Deuteromycetes families.
  • UsesDifenoconazole is a fungicide with broad-range activity, protecting yield and quality by foliar application or seed treatment. It provides long-lasting and curative activity against Ascomycetes, Basidiomycetes and Deuteromycetes. It is used against disease complexes in grapes, pome fruit, stone fruit, potatoes, sugar beet, oilseed rape, banana, ornamentals and various vegetable crops. It is also used as a seed treatment against a range of pathogens in wheat and barley.
  • DefinitionChEBI: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
  • Agricultural UsesFungicide: For suppression of fungi diseases in crops and seeds.
  • Trade nameCGA 169374®; DIVIDEND®; DIVIDEND® EXTREME FUNGICIDE; HELIX®; SCORE®; TECHNICAL CGA-169374®
  • Metabolic pathwayThere is limited published information on the metabolism of difenoconazole. It is slowly dissipated in soils, and metabolism in plants involves rupture of the triazole linkage or oxidation of the phenyl ring followed by conjugation.
  • DegradationDifenoconazole is stable to hydrolysis and is thermally stable to 150 °C. DT50 of difenocoazole in natural sunlight was 145 days.
  • ReferencesKwok, Iris M‐Y., and R. Thomas Loeffler. "The biochemical mode of action of some newer azole fungicides." Pest Management Science 39.1 (1993): 1-11.
    Wang, K., J. X. Wu, and H. Y. Zhang. "Dissipation of difenoconazole in rice, paddy soil, and paddy water under field conditions." Ecotoxicology and environmental safety 86 (2012): 111-115.
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