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Ambroxol

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Ambroxol Basic information
Ambroxol Chemical Properties
  • Melting point:233-234 C
  • Boiling point:468.6±45.0 °C(Predicted)
  • Density 1.5863 (rough estimate)
  • refractive index 1.6220 (estimate)
  • storage temp. 2-8°C
  • pka15.12±0.40(Predicted)
  • CAS DataBase Reference18683-91-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceAmbroxol(18683-91-5)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/37/38
  • Safety Statements 36-26
  • WGK Germany 3
  • RTECS GV8423000
Ambroxol Usage And Synthesis
  • OriginatorMucosolvan,Thomae,W. Germany,1980
  • Usesexpectorant
  • Manufacturing Process6.5 g of N-(trans-p-hydroxycyclohexyl)-(2-aminobenzyl)-amine were dissolved in a mixture of 80 cc of glacial acetic acid and 20 cc of water, and then 9.6 g of bromine were added dropwise at room temperature while stirring the solution. After all of the bromine had been added, the reaction mixture was stirred for two hours more and was then concentrated in a water aspirator vacuum. The residue was taken up in 2 N ammonia, the solution was extracted several times with chloroform, and the organic extract solutions were combined and evaporated. The residue, raw N-(trans-phydroxycyclohexyl)-( 2-amino-3,5-dibromobenzyl)-amine, was purified with chloroform and ethyl acetate over silica gel in a chromatographic column, the purified product was dissolved in a mixture of ethanol and ether, and the solution was acidified with concentrated hydrochloric acid. The precipitate formed thereby was collected and recrystallized from ethanol and ether, yielding N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)-amine hydrochloride, MP 233-234.5°C (decomposition).
  • Therapeutic FunctionExpectorant
Ambroxol Preparation Products And Raw materials
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