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Phenoxybenzamine hydrochloride

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Phenoxybenzamine hydrochloride Basic information
Phenoxybenzamine hydrochloride Chemical Properties
Safety Information
  • Hazard Codes Xn
  • Risk Statements 22-40
  • Safety Statements 22-36/37/39-45
  • WGK Germany 3
  • RTECS DP3750000
  • HS Code 2922299000
Phenoxybenzamine hydrochloride Usage And Synthesis
  • Chemical PropertiesWhite Solid
  • Chemical PropertiesWhite crystalline solid or powder. Odorless.
  • Usesalpha adrenergic blocker
  • UsesAn irreversible α-antagonist. Used in the treatment of hypertension, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers.
  • brand nameDibenzyline (WellSpring).
  • General DescriptionWhite crystalline powder. Melting point 137.5-140°C. Used as an antihypertensive drug.
  • General DescriptionPhenoxybenzamine (Dibenzyline) an old but powerfulα-blocker, is a haloalkylamine that blocksα1- and α2-receptors irreversibly. Phenoxybenzamine administrationhas been described as producing a “chemical sympathectomy”because of its selective blockade of the excitatory responses of smooth muscle and of the heart muscle.Although phenoxybenzamine is capable of blockingacetylcholine, histamine, and serotonin receptors, itsprimary pharmacological effects, especially that of vasodilation,may be attributed to its α-adrenergic blockingcapability. As would be expected of a drug that producessuch a profound α-blockade, administration is frequentlyassociated with reflex tachycardia, increased cardiacoutput, and postural hypotension. There is also evidenceindicating that blockade of presynaptic 2-receptorscontribute to the increased heart rate produced byphenoxybenzamine.
  • Air & Water ReactionsLight sensitive and may be sensitive to exposure to air . Insoluble in water.
  • Fire HazardFlash point data are not available for Phenoxybenzamine hydrochloride , but Phenoxybenzamine hydrochloride is probably combustible.
  • Clinical UseOral phenoxybenzamine is used for the preoperativemanagement of patients with pheochromocytoma and in thechronic management of patients whose tumors are notamenable to surgery. Only about 20% to 30% of an oraldose is absorbed.
  • Safety ProfileConfumed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal,intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl-.
  • Potential ExposureUsed as an antihypertensive drug
  • Veterinary Drugs and TreatmentsPhenoxybenzamine is used in small animals primarily for its effect in reducing internal urethral sphincter tone in dogs and cats when urethral sphincter hypertonus is present. It can also be used to treat the hypertension associated with pheochromocytoma prior to surgery or as adjunctive therapy in endotoxicosis.
    In horses, phenoxybenzamine has been used for preventing or treating laminitis in its early stages and to treat secretory diarrheas.
  • CarcinogenicityPhenoxybenzamine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
  • ShippingUN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials
  • IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Sensitive upon exposure to light and air. May form unstable and explosive peroxides upon standing.
  • Waste DisposalUse a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Phenoxybenzamine hydrochloride (63-92-3)Related Product Information
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