6-Hydroxyflavone (6-100 mg/kg; Oral administration; Single dose; 45 minutes before test) has anti-anxiety effect in mouse model[4].
6-Hydroxyflavone (25-50 mg/kg; Intraperitoneal injection; 15 days) shows protective effect in Cisplatin (HY-17394) -induced nephrotoxicity rat model[5].
| Animal Model: | Male ICR mice (20-36 g)[4] |
| Dosage: | 6, 12, 25, 50 and 100 mg/kg |
| Administration: | Oral administration (p.o.); Single dose; 45 minutes before test |
| Result: | Showed anti-anxiety effects on behavioral tests.
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| Animal Model: | Cisplatin (HY-17394) treated male Sprague-Dawley rats (200-250 g)[5] |
| Dosage: | 25 and 50 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); 15 days |
| Result: | Significantly attenuated the Cisplatin associated detrimental changes in the body weight, and serum levels of creatinine and urea at both 25 mg/kg and 50 mg/kg.
Preserved the renal histoarchitecture from the toxicological influence of Cisplatin.
Reduced the Cisplatin-induced lipid peroxidation and corrected the renal antioxidant status.
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