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Baicalein

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Baicalein Basic information
Baicalein Chemical Properties
  • Melting point:256-271 °C(lit.)
  • Boiling point:373.35°C (rough estimate)
  • Density 1.3280 (rough estimate)
  • refractive index 1.5000 (estimate)
  • storage temp. 2-8°C
  • form Yellow solid
  • pka6.31±0.40(Predicted)
  • Merck 14,942
  • BRN 272683
  • InChIKeyFXNFHKRTJBSTCS-UHFFFAOYSA-N
  • CAS DataBase Reference491-67-8(CAS DataBase Reference)
Safety Information
  • Hazard Codes Xi,Xn
  • Risk Statements 36/37/38-20/21/22
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS DJ3100898
  • Hazard Note Irritant
  • HS Code 29329990
MSDS
Baicalein Usage And Synthesis
  • Chemical PropertiesYellow Crystalline Solid
  • UsesBaicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. Several different functions of baicalein have been reported. Platelet 12-lipoxygenase is inhibited by baicalein with an ID50 value of 0.12 μM, with minimal inhibition of platelet cyclooxygenase-1 (IC50 = 0.83 mM). Baicalein inhibits lipid peroxidation, as assessed by production of TBARS, with an IC50 value of 5 μM. In addition to these effects, baicalein may play a role in apoptosis, as the compound inhibits cell growth of three human hepatocellular carcinoma cell lines with IC50 values ranging from 17-70 μg/ml.
  • Usesantiviral (HIV)
  • UsesAn inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the fl avonoid component of Nepalese and Sino-Japanese crude drugs.
  • Usesinhibitor of lipoxidase and leukotriene biosynthesis
  • UsesAn inhibitor of Ca2+ uptake, 5-LO, and 12-LO
  • DefinitionChEBI: A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7.
  • Biological ActivityInhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 mM respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G1 and G2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Anti-inflammatory in vivo .
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