Gardenin A (0.1-25 mg/kg; p.o.; single dose) has neuropharmacological, including sedative, anxiolytic, antidepressant, and anticonvulsant actions in mice[2].
Gardenin A (1-10 mg/kg; p.o.; single dose) does not affect locomotor coordination in mice and delayed the onset of convulsions[2].
| Animal Model: | Male Balb/c mice (24-32 g)[2] |
| Dosage: | 1 mg/kg, 10 mg/kg, 25 mg/kg |
| Administration: | Oral gavage; single dose |
| Result: | Showed sedative effects at a dose of 25 mg/kg, which increased the duration of sleep but did not alter sleep onset. |
