Flusilazole is a broad spectrum fungicide used to control fungal
disease caused by pathogens of the Ascomycetes, Basidiomycetes and
Deuteromycetes families. Flusilazole exhibits curative and preventative
activities and is recommended for use in agriculture, horticulture and
viticulture. Diseases controlled include eyespot, mildew, and rusts of
cereals, cercospora and rust of sugar beets, leaf spots of oilseed rape,
scab and mildew of pome and stone fruits, mildew and black rot of
grapes and Sigatoka disease of bananas.
Flusilazole is a silicon-containing triazole fungicide. Flusilazole is used to control fungal infections on a variety of fruit and vegetable crops
ChEBI: Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an environmental contaminant, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an antifungal agrochemical. It is a member of monofluorobenzenes, a member of triazoles, an organosilicon compound, a conazole fungicide and a triazole fungicide.
Flusilazole is stable to aqueous hydrolytic and photolytic degradation.
Although flusilazole is relatively stable in soil and is detected in plant and
animal samples, numerous degradation products have been reported. The
primary metabolic pathway involves the cleavage of the methylenesilicon
or/and methylene-triazole linkage. Another primary pathway
involves aryl hydroxylation followed by conjugation. The primary
metabolic/degradation pathways of flusilazole in soil, plant and animals
are presented in Scheme 1.
Aqueous hydrolysis and photolysis are not sigruficant degradation pathways
for flusilazole (1). Flusilazole was stable (<5% decomposition) in
sterile buffers at pH 5, 7 and 9 (25 °C) for 34 days (Cadwgan, 1983). No
significant degradation was observed when fusilazole was irradiated with
simulated sunlight for 30 days at 300-450 nm in sterile buffer solution at
pH 7 (Carter, 1986).
