antiinflammatory, analgesic
Loxoprofen is a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. Loxoprofen becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted to its active trans-alcohol metabolite following ora
administration.
Ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide were reacted with ethyl 2-(4-chloro-phenyl)propionate at 80 C for 2 h. The product obtained was reacted with 47% hydrobromic acid and hydrolyzed and decarboxylated to give loxoprofen.
