ChemicalBook > Product Catalog > API > Vitamins and Minerals medicines > Vitamin C drugs > Sodium ascorbate
Sodium ascorbate Chemical Properties
- Melting point:220 °C (dec.)(lit.)
- alpha 104 º (c=1, H2O 25 ºC)
- Boiling point:235 °C
- Density 1.66
- refractive index 105.5 ° (C=10, H2O)
- storage temp. Store at RT.
- solubility H2O: 50 mg/mL
- form powder
- color white to slightly yellow
- PHpH (20g/l, 25℃) : 6.5～8.0
- optical activity[α]20/D +105±2°, c = 5% in H2O
- Water Solubility 620 g/L (20 ºC)
- Merck 14,830
- BRN 3767246
- Stability:Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference134-03-2(CAS DataBase Reference)
- EPA Substance Registry SystemSodium ascorbate (134-03-2)
Sodium ascorbate Usage And Synthesis
- DescriptionSodium ascorbate is sodium salt of ascorbic acid (commonly known as vitamin C), which is approved for use as a food additive in many countries. Sodium ascorbate is consisted of a combination of sodium and vitamin C, which commonly serve as an antioxidant and an acidity regulator in pharmaceutical manufacturing and in the food industry. In this mixture, sodium acts as a buffer, creating a less acidic supplement than those made entirely from vitamin C. It can be easier to tolerate if the digestive system is sensitive to acid. As a vitamin C supplement, it provides both sodium and vitamin C for human body, which is effective to prevent or treat vitamin C deficiency. Besides, studies have shown that taking sodium ascorbate is helpful with cancer prevention and treatment.
- Chemical PropertiesSodium ascorbate occurs as a white or slightly yellow-colored, practically odorless, crystalline powder with a pleasant saline taste.
- Chemical Propertieswhite to off-white solid
- UsesL-Ascorbic acid (Vitamin C) is a water soluble molecule used in a wide variety of applications, including cell culture, as a reducing agent that helps reduce oxidative stress.
- UsesAs antimicrobial and antioxidant in foodstuffs.
- UsesSodium Ascorbate is an antioxidant that is the sodium form of ascorbic acid. it is soluble in water and provides a nonacidic taste. a 10% aqueous solution has a ph of 7.3–7.6. in water, it readily reacts with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. one part sodium ascorbate is equivalent to 1.09 parts of sodium erythorbate. see ascorbic acid.
- DefinitionChEBI: An organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion.
- Production MethodsAn equivalent amount of sodium bicarbonate is added to a solution of ascorbic acid in water. Following the cessation of effervescence, the addition of propan-2-ol precipitates sodium ascorbate.
- brand nameAscorbin (Marion Merrell Dow).
- General DescriptionMinute crystals or white powder. pH of aqueous solutions 5.6 to 7.0 or even higher (a 10% solution, made from a commercial grade, may have a pH of 7.4 to 7.7).
- Air & Water ReactionsWater soluble. Aqueous solutions are subject to quick air oxidation at pH greater than 6.0.
- Reactivity ProfileA weak base. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
- Health HazardSYMPTOMS: Ingestion of 10 grams or more of this type of compound may cause diarrhea.
- Fire HazardFlash point data for Sodium ascorbate are not available. Sodium ascorbate is probably combustible.
- Pharmaceutical ApplicationsSodium ascorbate is used as an antioxidant in pharmaceutical
formulations, and also in food products where it increases the
effectiveness of sodium nitrite against growth of Listeria monocytogenes
in cooked meats. It improves gel cohesiveness and sensory
firmness of fiberized products regardless of vacuum treatment.
It is also used therapeutically as a source of vitamin C in tablets and parenteral preparations.
- Safety ProfileHuman mutation data reported. When heated to decomposition it emits toxic fumes of Na2O.
- SafetyThe parenteral administration of 0.25-1.00 g of sodium ascorbate,
given daily in divided doses, is recommended in the treatment of
vitamin C deficiencies. Various adverse reactions have been
reported following the administration of 1 g or more of sodium
ascorbate, although ascorbic acid and sodium ascorbate are usually
well tolerated; see Ascorbic acid. There have been no reports of
adverse effects associated with the much lower concentrations of
sodium ascorbate and ascorbic acid, which are employed as
The WHO has set an acceptable daily intake of ascorbic acid, potassium ascorbate, and sodium ascorbate, as antioxidants in food, at up to 15 mg/kg body-weight in addition to that naturally present in food.
- storageSodium ascorbate is relatively stable in air, although it gradually
darkens on exposure to light. Aqueous solutions are unstable and
subject to rapid oxidation in air at pH > 6.0.
The bulk material should be stored in a well-closed nonmetallic container, protected from light, in a cool, dry place.
- IncompatibilitiesIncompatible with oxidizing agents, heavy metal ions, especially copper and iron, methenamine, sodium nitrite, sodium salicylate, and theobromine salicylate. The aqueous solution is reported to be incompatible with stainless steel filters.
- Regulatory StatusGRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IV preparations; oral tablets). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium ascorbate Preparation Products And Raw materials
- Calcium ascorbate dihydrate Sodium benzoate sodium Sodium ascorbate Sodium erythorbate ε-Caprolactone POLYCAPROLACTONE AVERAGE MN CA. 42 500 Sodium chloride Erythorbic Acid Sodium bicarbonate Sodium 4-hydroxybenzenesulfonate Hydroxy silicone oil Sodium citrate Ascoric Acid Diclofenac sodium Vitamin E Sodium sulfate 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
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