4-Nitrobiphenyl exists as yellow plates or needles..
Formerly used as an intermediate for
4-aminobiphenyl
4-Nitrobiphenyl has some uses as a plasticizer, fungicide, and
wood preservative.
Formerly in preparation of p-biphenylamine, q.v.
ChEBI: 4-Nitrobiphenyl is a member of biphenyls.
White to yellow needle-like crystalline solid with a sweetish odor.
4-Nitrobiphenyl is incompatible with the following: Strong reducers .
Toxic by ingestion and skin contact. Confirmed carcinogen.
p-Nitrobiphenyl (PNB) is a
urinary bladder carcinogen in dogs.
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx. See also NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS.
4-Nitrobiphenyl was formerly used in
the synthesis of 4-aminodiphenyl. It is presently used only
for research purposes; there are no commercial uses.
The case for the carcinogenicity of PNB
is supported by (1) the induction of urinary
bladder cancer in dogs after administration of
PNB; (2) the evidence that PNB is metabolized
in vivo to 4-aminobiphenyl (a potent carcinogen);
and (3) the possibility that the cases of
human urinary bladder cancer attributed to 4-
aminobiphenyl may also have been induced by
exposure to PNB.1
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Incompatible with strong reducing agents
such as hydrides, oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Keep away
from alkaline materials, strong bases, strong acids, oxoacids,
epoxides.
Incineration @ 982℃/2.0 seconds
(minimum) with scrubbing for nitrogen oxides
abatement.