4-Nitrobiphenyl exists as yellow plates or needles..
Formerly used as an intermediate for
4-aminobiphenyl
4-Nitrobiphenyl has some uses as a plasticizer, fungicide, and
wood preservative.
Formerly in preparation of p-biphenylamine, q.v.
ChEBI: 4-Nitrobiphenyl is a member of biphenyls.
White to yellow needle-like crystalline solid with a sweetish odor.
4-Nitrobiphenyl is incompatible with the following: Strong reducers .
Toxic by ingestion and skin contact. Confirmed carcinogen.
p-Nitrobiphenyl (PNB) is a
urinary bladder carcinogen in dogs.
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by intraperitoneal route. Moderately toxic by
ingestion. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NOx. See also NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS.
4-Nitrobiphenyl is no longer manufactured or used in the United States. Limited information is available on the health effects of 4-nitrobiphenyl. Acute (short-term) exposure to 4-nitrobiphenyl in humans results in irritation of the eyes, mucous membranes, and respiratory tract, such as headache, nausea, vomiting, and fatigue. Chronic (long-term) exposure to high concentrations of 4-nitrobiphenyl in workers has resulted in effects on the peripheral and central nervous systems as well as the liver and kidney. No information on the reproductive, developmental, or carcinogenic effects of 4-nitrobiphenyl in humans is available. EPA has not classified 4-nitrobiphenyl for carcinogenicity. 4-Nitrobiphenyl is no longer manufactured, imported, used, or sold in the United States.
4-Nitrobiphenyl was formerly used in
the synthesis of 4-aminodiphenyl. It is presently used only
for research purposes; there are no commercial uses.
The case for the carcinogenicity of PNB
is supported by (1) the induction of urinary
bladder cancer in dogs after administration of
PNB; (2) the evidence that PNB is metabolized
in vivo to 4-aminobiphenyl (a potent carcinogen);
and (3) the possibility that the cases of
human urinary bladder cancer attributed to 4-
aminobiphenyl may also have been induced by
exposure to PNB.1
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Incompatible with strong reducing agents
such as hydrides, oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Keep away
from alkaline materials, strong bases, strong acids, oxoacids,
epoxides.
Incineration @ 982℃/2.0 seconds
(minimum) with scrubbing for nitrogen oxides
abatement.
