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2,4-Dinitrofluorobenzene Basic information
2,4-Dinitrofluorobenzene Chemical Properties
  • Melting point:25-27 °C(lit.)
  • Boiling point:178 °C25 mm Hg(lit.)
  • Density 1.482 g/mL at 25 °C(lit.)
  • refractive index n20/D 1.569(lit.)
  • Flash point:>230 °F
  • storage temp. 2-8°C
  • solubility chloroform: 0.1 g/mL, clear
  • form Liquid or Low Melting Crystals
  • color Yellow to brownish
  • Specific Gravity1.482
  • Water Solubility 400 mg/L (25 ºC)
  • Merck 14,4172
  • BRN 398632
  • Stability:Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
  • CAS DataBase Reference70-34-8(CAS DataBase Reference)
  • NIST Chemistry ReferenceBenzene, 1-fluoro-2,4-dinitro-(70-34-8)
  • EPA Substance Registry System2,4-Dinitrofluorobenzene (70-34-8)
Safety Information
2,4-Dinitrofluorobenzene Usage And Synthesis
  • Chemical PropertiesYellow solid
  • UsesA substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria.
  • DefinitionChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions.
  • General DescriptionClear yellow crystals or yellow crystalline solid.
  • Air & Water ReactionsSlightly soluble in water.
  • Reactivity ProfileReacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.
  • Fire Hazard2,4-Dinitrofluorobenzene is probably combustible.
  • Contact allergensDNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata
  • Safety ProfilePoison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES.
  • Purification MethodsCrystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.]
2,4-Dinitrofluorobenzene Preparation Products And Raw materials
2,4-Dinitrofluorobenzene(70-34-8)Related Product Information