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2-Nitrofluorene

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2-Nitrofluorene Basic information
2-Nitrofluorene Chemical Properties
  • Melting point:156-158 °C(lit.)
  • Boiling point:350.9°C (rough estimate)
  • Density 1.1868 (rough estimate)
  • refractive index 1.6060 (estimate)
  • form Powder
  • color White to brown
  • Water Solubility Insoluble
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference607-57-8(CAS DataBase Reference)
  • NIST Chemistry ReferenceFluorene, 2-nitro-(607-57-8)
  • EPA Substance Registry System2-Nitrofluorene (607-57-8)
Safety Information
MSDS
2-Nitrofluorene Usage And Synthesis
  • Chemical Propertiescream powder
  • DefinitionChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.
  • General DescriptionCream-colored solid.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileAromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.
  • Health HazardACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.
  • Safety ProfileConfirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
  • Metabolic pathwayLung microsomal metabolism of 2-nitrofluorene (NF) increases in parallel with the accumulation of P-450b homologous mRNA and microsomal cytochrome P- 450b protein concentration. The formation of the major metabolite, and potent mutagen, 9-hydroxy-2- nitrofluorene (9-OHNF) is significantly inhibited by the addition of polyclonal anti-P-450b-IgG, and by the addition of the inhibitor, proadifen, to incubations with lung microsomal protein.
  • Purification MethodsCrystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]
2-Nitrofluorene Preparation Products And Raw materials
2-Nitrofluorene(607-57-8)Related Product Information
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