(R)-1-Boc-3-Aminopiperidine

915226-43-6

188111-79-7

The general procedure for the synthesis of (R)-1- tert-butyl tert-butyloxycarbonyl-3-aminopiperidine from (R)-3-carbamoylpiperidine-1-carboxylic acid is as follows: in Example 28, (R)-1-(tert-butoxycarbonyl)-3-aminopiperidine was prepared as follows: firstly, (R)-1-(tert-butoxycarbonyl)piperidine amide (9 g of a solution, wherein the net weight of (R)-1 -(tert-butoxycarbonyl)piperidine amide is 0.7 g), sodium hydroxide (1.3 g, 10 equiv) and sodium hypochlorite aqueous solution (2.2 g, 10 equiv) are combined. Oxycarbonyl)piperidinamide has a net weight of 0.7 g), sodium hydroxide (1.3 g, 10 eq.) and aqueous sodium hypochlorite (2.2 g, 1.1 eq.) were mixed. The reaction mixture was stirred at 15 to 25°C for 16 hours. Upon completion of the reaction, the aqueous layer was separated and removed, followed by evaporation of the solvent under reduced pressure. Toluene (10 mL) and saturated brine (5 mL) were added to the residue and the aqueous layer was again separated and removed. Finally, the solvent was evaporated under reduced pressure to afford (R)-1-tert-butoxycarbonyl-3-aminopiperidine, the product was a yellow oil (0.7 g, net weight: 0.5 g, yield: 80%).