软木肟酸
软木肟酸 性质
| 熔点 | 153-155 °C(lit.) |
|---|---|
| 密度 | 1.219±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于水中 |
| 酸度系数(pKa) | 9.18±0.20(Predicted) |
| 形态 | 冻干粉 |
| 颜色 | 白色至浅米色 |
| 稳定性 | 吸湿性 |
软木肟酸 用途与合成方法
| Target | Value |
|
HDAC1
(Cell-free assay) | 0.25 μM |
|
HDAC3
(Cell-free assay) | 0.3 μM |
Suberoyl bis-hydroxamic acid (10, 20 or 50 μM; 24 hours) combination with TRAIL improves apoptosis extent, and when TRAIL is combined with 20 μM SBHA (itself causing only 10–15% apoptosis), resulting in 45–50% cell death.Suberoyl bis-hydroxamic acid (20-50 μM; 10-20 hours) alone has little effect on the expression of the proteins Bcl-xL, Mcl-1, and has albeit mildeffect on Bax. When it combines with TRAIL,which increases the ratio of relative protein expression of Bcl-xL and Bax in early periods, while the change in the ratio of Mcl-1 and Bax increases later in MM-BI and Ist-Mes2 cells.Suberoyl bis-hydroxamic acid (30 μM; 6 hours) causes accumulation of acetylated histone H4 in MEL cells.
Apoptosis Analysis
| Cell Line: | MM-BI and Ist-Mes2 cells |
| Concentration: | 10 μM, 20 μM or 50 μM |
| Incubation Time: | 24 hours |
| Result: | Showed a cooperative effect in cell apoptosis. |
Suberoyl bis-hydroxamic acid (intraperitoneal injection; 200 mg/kg; every 2 days; 12 days) reveals a marked increase in the active form of Notch1 (NICD) with a concomitant decrease in ASCL1. It reduces the MTC tumor growth.
| Animal Model: | Nude mice injected with human MTC cells |
| Dosage: | 200 mg/kg |
| Administration: | Intraperitoneal injection; every 2 days; 12 days |
| Result: | Resulted in an average 55% inhibition of tumor growth in SBHA treatment group. |
软木肟酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-W009776 | 软木肟酸 | 38937-66-5 | 50mg | 100 |
| 2024-01-25 | HY-W009776 | 软木肟酸 | 38937-66-5 | 10mM * 1mLin DMSO | 110 |
