1-Bromopentane CAS#: 110-53-2

1-Bromopentane

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1-Bromopentane Basic information

1-Bromopentane Chemical Properties

Melting point:−95 °C(lit.)
Boiling point:130 °C(lit.)
Density 1.218 g/mL at 25 °C(lit.)
vapor density >1 (vs air)
refractive index n20/D 1.444(lit.)
Flash point:88 °F
storage temp. Flammables area
solubility H2O: insoluble
form Liquid
color Clear colorless to light yellow
Water Solubility practically insoluble
Merck 14,602
BRN 1730981
Stability:Stable. Flammable. Incompatible with strong oxidizing agents, strong bases.
InChIKeyYZWKKMVJZFACSU-UHFFFAOYSA-N
CAS DataBase Reference110-53-2(CAS DataBase Reference)
NIST Chemistry ReferencePentane, 1-bromo-(110-53-2)
EPA Substance Registry SystemPentane, 1-bromo- (110-53-2)

Safety Information

MSDS

1-Bromopentane Usage And Synthesis

Chemical Propertiesliquid
Uses1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α, γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase.
Synthesis Reference(s)Journal of the American Chemical Society, 86, p. 5037, 1964 DOI: 10.1021/ja01076a084
Safety ProfileModerately toxic byintraperitoneal route. Slightly toxic by inhalation. Whenheated to decomposition it emits toxic vapors of Br^-.
Purification MethodsWash the bromide with conc H2SO4, then water, 10% Na2CO3 solution, again with water, dry with CaCl2 or K2CO3, and fractionally distil it just before use. [Beilstein 1 IV 312.]

1-Bromopentane Preparation Products And Raw materials

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