Chemical Properties
liquid
Uses
1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α,
γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase.
Uses
1-Bromopentane is used in a multitude of organic synthesis. It is used in iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 5037, 1964
DOI: 10.1021/ja01076a084
General Description
1-Bromopentane undergoes phase transfer catalysed alkylation reaction with 2′-hydroxy acetophenone using tetrabutyl ammonium bromide as catalyst.
Safety Profile
Moderately toxic byintraperitoneal route. Slightly toxic by inhalation. Whenheated to decomposition it emits toxic vapors of Br
-.
Purification Methods
Wash the bromide with conc H2SO4, then water, 10% Na2CO3 solution, again with water, dry with CaCl2 or K2CO3, and fractionally distil it just before use. [Beilstein 1 IV 312.]
