Epalrestat

• in the dahomey larvae diet fed forDrosophila
• for non-irradiated and X-ray irradiated human aldose reductase
• to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

5718-83-2

15174-47-7

82158-86-9

General procedure for the synthesis of the compound (CAS:82158-86-9) from 3-carboxymethyl bypassed tannin and trans-α-methyl cinnamaldehyde: Rhodanine-3-acetic acid (131.0 g) was dissolved in 700 mL of N,N-dimethylformamide (DMF), followed by a slow addition to the reaction mixture at 25-35°C of (E)-2-methyl-3-phenyl Acrolein (100.0 g) and 200 mL of DMF. next, a solution of ammonium acetate (63.27 g) dissolved in 60 mL of water was added to the reaction system, maintained at a temperature of 30-35°C and stirred for 4 hours. Upon completion of the reaction, the reaction mixture was cooled to 10-15°C. At this temperature, concentrated hydrochloric acid (100.0 g) was slowly added and the reaction temperature was maintained at 10-15°C for 2 hours. At the end of the reaction, the reaction mixture was filtered and the solid product was washed with DMF. Finally, the product was dried by rotary evaporation for 2-4 hours to give 2-((Z)-5-((E)-2-methyl-3-phenylpropenyl)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid in the yield of 260.50 g. The reaction was carried out at a temperature of 10-15°C for 2 hours.