Amyl salicylate

Amyl salicylate, also called isoamyl salicylate, is a colourless, transparent liquid with a delicate floral fragrance. It is insoluble in water but readily soluble in organic solvents, including diethyl ether, acetic acid, ethanol, acetone, benzene, and carbon tetrachloride.

Apparently has not been reported to occur in nature.

cleaning products
cosmetics
food and beverages
personal care

ChEBI: Amyl salicylate is a salicylate ester. It has an aromatic herbaceous orchid hay chamomile mild-floral medicinal green fougere carnation hyacinth trefle root-beer fruit grape lavender.

By esterification of salicylic acid with the isomeric amyl alcohols obtained from fusel oil and other sources.

The LD₅₀ value iv in dogs was reported as 0.5-0.8 g/kg(Fassett, 1963).Human testing. A maximization test(Kligman, 1966) was carried out on 25 volunteers. The material was tested at a concentration of 10% in petrolatum and produced no reactions(Kligman, 1970).Aspirin-containing drugs will cause exacerbation in some patients with chronic urticaria. The action is probably due to the salicylate radical. It is suggested that aspirin acts in chronic urticaria by enhancing the effect of histamine in the skin(Moore- Robinson & Warin, 1967).

Most of the esters of salicylic acid are decomposed to salicylic acid in the body and excreted as such. Besides the unchanged acid, salicuric acid, genticic acid and salicyl glucuronide have been known to be excreted. The lower esters of salicylic acid decompose more readily than the higher esters and as a consequence, little of the amyl ester is split. The whole subject of salicylic esters is covered in an extensive literature by Gross & Greenberg(1948).