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Cefpiramide acid

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Cefpiramide acid Basic information
Cefpiramide acid Chemical Properties
  • Melting point:213-215° (dec)
  • Density 1.75±0.1 g/cm3(Predicted)
  • pka2.62±0.50(Predicted)
Safety Information
  • HS Code 2941906000
Cefpiramide acid Usage And Synthesis
  • UsesAntibacterial.
  • DefinitionChEBI: A third-generation cephalosporin antibiotic with [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and (R)-2-{[(4-hydroxy-6-methylpyridin-3-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectiv ly, of the cephem skeleton. It has a broad spectrum of antibacterial activity.
  • Antimicrobial activityA semisynthetic parenteral cephalosporin. It exhibits a broad range of activity, which includes Ps. aeruginosa, though the overall activity is rather modest. It is moderately stable to most β-lactamases but less so than ceftazidime or cefpirome.
    In volunteers given 0.5 or 1 g by intravenous bolus, the mean plasma concentration shortly after injection was around 150 or 300 mg/L, respectively. There was no accumulation when the same doses were repeated every 12 h for 11 doses. It is highly bound to plasma protein (c. 95%). The mean plasma half-life is around 5 h. Less than one-quarter of the dose appears in the urine over 24 h; the rest is excreted in bile and high concentrations are found in feces. Renal impairment has little effect on elimination in patients with normal liver function.
    Diarrhea may be associated with marked suppression of gut flora resulting from biliary excretion of the drug. The molecule includes a C-3 methylthiotetrazole side chain and side effects associated with that substituent are to be expected.
    It is available in Japan.
Cefpiramide acid Preparation Products And Raw materials
Cefpiramide acid(70797-11-4)Related Product Information
Cefpiramide acidSupplierMore
  • Company Name:Qilu Pharmaceutical Co. Ltd. Gold
  • Tel:0531-83128685-
  • Email:hui.ma@qilu-pharma.com
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  • Company Name:Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd. Gold
  • Tel:13343472658 027-83850122-
  • Email:918571372@qq.com
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  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Email:jkinfo@jkchemical.com;market6@jkchemical.com
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  • Company Name:Pure Chemistry Scientific Inc.
  • Tel:001-857-928-2050 or 1-888-588-9418
  • Email:sales@chemreagents.com
  •  
  • Company Name:Chemsky(shanghai)International Co.,Ltd.
  • Tel:021-50135380
  • Email:shchemsky@sina.com
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