Adiphenine
hydrochloride,Spectrum Chemicals and
Laboratory Products, Inc.
Adiphenine hydrochloride is an anticholinergic. Adiphenine hydrochloride is used as an antispasmodic.
10.6 parts of α,α-diphenylacetic acid are treated with thionyl chloride and the
diphenylacetylchloride thus produced is caused to react with 5.9 parts of
diethylaminoethanol at 120°C. The α,α-diphenylacetic acid, 2-
(diethylamino)ethanol ester hydrochloride thus produced is crystallized from
ethyl acetate; it melts at 113-114°C.
Anticholinergic, Spasmolytic, Smooth muscle relaxant
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED50 of 62 mg/kg in mice[3].
