盐酸阿地芬宁
盐酸阿地芬宁 性质
| 熔点 | 113-114° |
|---|---|
| 密度 | 1.0555 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | Room Temperature |
| 溶解度 | DMSO（微溶）、甲醇（微溶）、水（微溶） |
| 形态 | 固体 |
| 颜色 | 白色 |
| Merck | 14,161 |
| InChI | InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,19H,3-4,15-16H2,1-2H3;1H |
| InChIKey | LKPINBXAWIMZCG-UHFFFAOYSA-N |
| SMILES | C(C(=O)OCCN(CC)CC)(C1=CC=CC=C1)C1=CC=CC=C1.Cl |
| CAS 数据库 | 50-42-0(CAS DataBase Reference) |
盐酸阿地芬宁 用途与合成方法
| Target | Value |
|
α3β4 nAChR
(Cell-free assay) | 1.8 μM |
|
α1 nAChR
(Cell-free assay) | 1.9 μM |
|
α4β2 nAChR
(Cell-free assay) | 3.7 μM |
|
α4β4 nAChR
(Cell-free assay) | 6.3 μM |
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC
50
of 1.9 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC
50
of 1.8 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC
50
s of 3.7 and 6.3 µM, respectively.
Adiphenine (50-200 µM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED 50 of 62 mg/kg in mice.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22 |
| 安全说明 | 36 |
| WGK Germany | 3 |
| RTECS号 | AH2625000 |
| 海关编码 | 2922.19.7000 |
| 毒性 | LD50 i.p. in mice: 0.24 g/kg (Burtner, Cusic) |
盐酸阿地芬宁 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-B0379AR | 盐酸阿地芬宁 | 50-42-0 | 10 mg | 300 |
| 2026-09-15 | HY-B0379AR | 盐酸阿地芬宁 | 50-42-0 | 25 mg | 440 |
