盐酸阿地芬宁
盐酸阿地芬宁 性质
熔点 | 113-114° |
---|---|
密度 | 1.0555 (rough estimate) |
折射率 | 1.5400 (estimate) |
储存条件 | Room Temperature |
溶解度 | DMSO(微溶)、甲醇(微溶)、水(微溶) |
形态 | 固体 |
颜色 | 白色 |
Merck | 14,161 |
InChIKey | LKPINBXAWIMZCG-UHFFFAOYSA-N |
CAS 数据库 | 50-42-0(CAS DataBase Reference) |
盐酸阿地芬宁 用途与合成方法
Target | Value |
α3β4 nAChR
(Cell-free assay) | 1.8 μM |
α1 nAChR
(Cell-free assay) | 1.9 μM |
α4β2 nAChR
(Cell-free assay) | 3.7 μM |
α4β4 nAChR
(Cell-free assay) | 6.3 μM |
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α1*-nAChR in a dose-dependent manner in TE671/RD cells, with an IC
50
of 1.9 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α3α4*-nAChR in a dose-dependent manner in SH-SY5Y cells, with an IC
50
of 1.8 µM.
Adiphenine (10 nM-1 mM; 3 min) blocks the function of α4β2- and α4β4-nAChR in a dose-dependent manner in SH-EP1 cells, with IC
50
s of 3.7 and 6.3 µM, respectively.
Adiphenine (50-200 µM; 30-60 s) decreases the frequency of ACh-induced single-channel currents in HEK 293 cells.
Adiphenine (i.p.) prevents the hindleg tonic-extensor component of maximal electroshock seizures (MES), with an ED 50 of 62 mg/kg in mice.
安全信息
危险品标志 | Xn |
---|---|
危险类别码 | 20/21/22 |
安全说明 | 36 |
WGK Germany | 3 |
RTECS号 | AH2625000 |
海关编码 | 2922.19.7000 |
毒性 | LD50 i.p. in mice: 0.24 g/kg (Burtner, Cusic) |
盐酸阿地芬宁 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-B0379A | 盐酸阿地芬宁 | 50-42-0 | 100mg | 200 |
2024-11-08 | HY-B0379A | 盐酸阿地芬宁 | 50-42-0 | 10mM * 1mLin DMSO | 220 |