clear yellow to green-yellow liquid
2',5'-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents.
2',5'-Dimethoxyacetophenone is obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide.
2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst.
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[2] Catalysis Communications, 2012, vol. 20, p. 68 - 70
[3] Tetrahedron Letters, 2013, vol. 54, # 23, p. 2924 - 2928
